Table 3 The information of the common differential expressed proteins from iTRAQ data and MS validation and the possible biological function for those three groups
Expression change | Protein name | Accession no. | Function /Biological_process |
|---|---|---|---|
C↑B↓ | Heterogeneous nuclear ribonucleoprotein H2 | Q6AY09 | RNA binding; nucleotide binding |
C↑B↓ | T-kininogen 2 | P08932 | cysteine-type endopeptidase inhibitor activity |
C↑B↓ | Protein Zyx | D4A7U1 | metal ion binding;zinc ion binding |
C↑B↓ | Adaptin ear-binding coat-associated protein 2 | Q6P756 | / protein transport |
C↑B↓ | Protein Ttc1 | Q66H09 | unknown |
C↑B↓ | NSFL1 cofactor p47 | O35987 | lipid binding; ubiquitin binding |
C↑B↓ | Toll-interacting protein | A2RUW1 | /inflammatory response; innate immune response; signal transduction |
C↑B↓ | Cystatin-C | P14841 | beta-amyloid binding; cysteine-type endopeptidase inhibitor activity; protease binding |
C↑B↓ | Microtubule-associated protein | F1LQB5 | unknown |
C↑B↓ | Anamorsin | Q5XID1 | / apoptotic process |
C↑B↓ | Zero beta-globin (Fragment) | Q63011 | heme binding; iron ion binding; oxygen binding; oxygen transporter activity |
C↑B↓ | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) (Predicted), isoform CRA_a NADH dehydrogenase | D4A2C6 | unknown |
C↑B↓ | (Ubiquinone) flavoprotein 3-like, isoform CRA_a | G3 V644 | unknown |
C↑B↓ | Microtubule-associated protein 1A | P34926 | actin binding |
C↑B↓ | Ndufa7 protein | A9UMV9 | NADH dehydrogenase (ubiquinone) activity |
C↑B↓ | PDZ and LIM domain protein 4 | P36202 | metal ion binding; zinc ion binding |
C↑B↓ | Atp8b2 protein | Q4V8A7 | unknown |
C↑B↓ | UPF0449 protein C19orf25 homolog | Q6AY72 | unknown |
C↑B↓ | Biphenyl hydrolase-like (Serine hydrolase) | Q3B8N9 | hydrolase activity |
C↑B↓ | Ubiquitin-fold modifier 1 (Fragment) | G5C7K5 | unknown |
C↑B↓ | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | Q6PCU8 | /electron transport chain |
C↑B↓ | Purkinje cell protein 4 (Fragment) | G5BG09 | unknown |
C↑B↓ | Ubiquitin-conjugating enzyme E2 B (Fragment) | G5BN13 | ATP binding;acid-amino acid ligase activity |
C↑B↓ | Neuromodulin | P07936 | /glial cell differentiation; nervous system development |
C↑B↓ | Protein Chchd2 | E9PT03 | unknown |
C↓B↑ | Histone H3.1 | Q6LED0 | DNA binding |
C↓B↑ | Galactosylceramidase | Q5YKG1 | cation binding; galactosylceramidase activity |
C↓B↑ | Interferon-induced, double-stranded RNA-activated protein kinase | Q63184 | ATP binding;double-stranded RNA binding;non-membrane spanning protein tyrosine kinase activity; protein serine/threonine kinase activity |
C↓B↑ | Histone H1.4 | P15865 | DNA binding |
C↓B↑ | Tyrosine--tRNA ligase, mitochondrial | Q5I0L3 | ATP binding RNA binding tyrosine binding tyrosine-tRNA ligase activity |
C↓B↑ | Pre-mRNA processing factor 8, isoform CRA_a | G3V6H2 | /mRNA splicing, via spliceosome |
C↓B↑ | Histone H3 | D3ZK97 | DNA binding |
CB↑ | Bifunctional epoxide hydrolase 2 | P80299 | 10-hydroxy-9-(phosphonooxy) octadecanoate phosphatase activity; 4-nitrophenylphosphatase activity; epoxide hydrolase activity; magnesium ion binding |
CB↑ | 60S ribosomal protein L23 | P62832 | structural constituent of ribosome |
CB↑ | NLR family member X1 | Q5FVQ8 | ATP binding |
CB↓ | Tropomyosin alpha-4 chain | P09495 | metal ion binding |
CB↓ | Calmodulin | G5BS71 | calcium ion binding |
CB↓ | Tropomyosin alpha-3 chain | Q63610 | / brain development |
CB↓ | Polypyrimidine tract-binding protein 1 (Fragment) | G5C5X1 | RNA binding;nucleotide binding |
CB↓ | Cytochrome b-c1 complex subunit 6, mitochondrial | Q5M9I5 | protein complex binding; ubiquinol-cytochrome-c reductase activity |
CB↓ | Glyceraldehyde 3-phosphate dehydrogenase (Fragment) | P97617 | nucleotide binding;oxidoreductase activity; acting on the aldehyde or oxo group of donors; NAD or NADP as acceptor |
CB↓ | Protein Srrm1 | D3ZD33 | / mRNA processing |
CB↓ | V-type proton ATPase subunit F | P50408 | ATPase activity; hydrogen ion transporting ATP synthase activity; proton-transporting ATPase activity |