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Table 3 The information of the common differential expressed proteins from iTRAQ data and MS validation and the possible biological function for those three groups

From: Comparative proteomic analysis of the brain and colon in three rat models of irritable bowel syndrome

Protein nameAccession no.Function /Biological_process
C↑B↓Heterogeneous nuclear ribonucleoprotein H2Q6AY09RNA binding; nucleotide binding
C↑B↓T-kininogen 2P08932cysteine-type endopeptidase inhibitor activity
C↑B↓Protein ZyxD4A7U1metal ion binding;zinc ion binding
C↑B↓Adaptin ear-binding coat-associated protein 2Q6P756/ protein transport
C↑B↓Protein Ttc1Q66H09unknown
C↑B↓NSFL1 cofactor p47O35987lipid binding; ubiquitin binding
C↑B↓Toll-interacting proteinA2RUW1/inflammatory response; innate immune response; signal transduction
C↑B↓Cystatin-CP14841beta-amyloid binding; cysteine-type endopeptidase inhibitor activity; protease binding
C↑B↓Microtubule-associated proteinF1LQB5unknown
C↑B↓AnamorsinQ5XID1/ apoptotic process
C↑B↓Zero beta-globin (Fragment)Q63011heme binding; iron ion binding; oxygen binding; oxygen transporter activity
C↑B↓LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) (Predicted), isoform CRA_a NADH dehydrogenaseD4A2C6unknown
C↑B↓(Ubiquinone) flavoprotein 3-like, isoform CRA_aG3 V644unknown
C↑B↓Microtubule-associated protein 1AP34926actin binding
C↑B↓Ndufa7 proteinA9UMV9NADH dehydrogenase (ubiquinone) activity
C↑B↓PDZ and LIM domain protein 4P36202metal ion binding; zinc ion binding
C↑B↓Atp8b2 proteinQ4V8A7unknown
C↑B↓UPF0449 protein C19orf25 homologQ6AY72unknown
C↑B↓Biphenyl hydrolase-like (Serine hydrolase)Q3B8N9hydrolase activity
C↑B↓Ubiquitin-fold modifier 1 (Fragment)G5C7K5unknown
C↑B↓NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialQ6PCU8/electron transport chain
C↑B↓Purkinje cell protein 4 (Fragment)G5BG09unknown
C↑B↓Ubiquitin-conjugating enzyme E2 B (Fragment)G5BN13ATP binding;acid-amino acid ligase activity
C↑B↓NeuromodulinP07936/glial cell differentiation; nervous system development
C↑B↓Protein Chchd2E9PT03unknown
C↓B↑Histone H3.1Q6LED0DNA binding
C↓B↑GalactosylceramidaseQ5YKG1cation binding; galactosylceramidase activity
C↓B↑Interferon-induced, double-stranded RNA-activated protein kinaseQ63184ATP binding;double-stranded RNA binding;non-membrane spanning protein tyrosine kinase activity; protein serine/threonine kinase activity
C↓B↑Histone H1.4P15865DNA binding
C↓B↑Tyrosine--tRNA ligase, mitochondrialQ5I0L3ATP binding RNA binding tyrosine binding tyrosine-tRNA ligase activity
C↓B↑Pre-mRNA processing factor 8, isoform CRA_aG3V6H2/mRNA splicing, via spliceosome
C↓B↑Histone H3D3ZK97DNA binding
CB↑Bifunctional epoxide hydrolase 2P8029910-hydroxy-9-(phosphonooxy) octadecanoate phosphatase activity; 4-nitrophenylphosphatase activity; epoxide hydrolase activity; magnesium ion binding
CB↑60S ribosomal protein L23P62832structural constituent of ribosome
CB↑NLR family member X1Q5FVQ8ATP binding
CB↓Tropomyosin alpha-4 chainP09495metal ion binding
CB↓CalmodulinG5BS71calcium ion binding
CB↓Tropomyosin alpha-3 chainQ63610/ brain development
CB↓Polypyrimidine tract-binding protein 1 (Fragment)G5C5X1RNA binding;nucleotide binding
CB↓Cytochrome b-c1 complex subunit 6, mitochondrialQ5M9I5protein complex binding; ubiquinol-cytochrome-c reductase activity
CB↓Glyceraldehyde 3-phosphate
dehydrogenase (Fragment)
P97617nucleotide binding;oxidoreductase activity; acting on the aldehyde or oxo group of donors; NAD or NADP as acceptor
CB↓Protein Srrm1D3ZD33/ mRNA processing
CB↓V-type proton ATPase subunit FP50408ATPase activity; hydrogen ion transporting ATP synthase activity; proton-transporting ATPase activity
  1. a) B brain, C colon b) ↑:upregulated, ↓:downregulated