Fig. 2

Gene ontology (GO) enrichment analysis and protein–protein interaction (PPI) network construction. (a) The top 20 GO (biological process, BP) enrichment terms of the differentially expressed proteins (DEPs); (b) The top 20 GO (molecular function, MF) enrichment terms of the DEPs; (c) The top 20 GO (cellular component, CC) enrichment terms of the DEPs; (d) PPI network of the DEPs involved in important pathways. The nodes represent DEPs, and the edges between the nodes indicate interactions between two connecting DEPs. The node colors indicate the betweenness of the node interaction: the more red the color, the larger the betweenness, indicating a stronger influence in the network. The node sizes indicate the degree of interaction between nodes: the larger the size, the higher the degree, indicating stronger stability in the network. The node shapes represent upregulated proteins (ellipse) or downregulated proteins (diamond). The degrees of edge width represent the protein–protein interaction scores