Fig. 5

Proteomic kinases profiles in EESCC and EDAC. a Distribution and the number of the seven major kinases types in EESCC (purple) and EDAC (red). b Bar charts showing the differential proportion of major kinases types in EESCC (purple) and EDAC (red). c Heatmap representing the expression of the proteins of major kinases types in EESCC and EDAC at the protein level. d Heatmap representing the expression of the proteins of major kinases types in EESCC and EDAC at the phosphoprotein level. e Enrichment of the kinases and the downstream substates showing the dominant pathways in EESCC (purple) and EDAC (red). P value < 0.05 and FDR q value < 0.3 were considered as significant enrichment. f Heatmap showing the expression of the inhibitors (FDA drug) to kinases (top) (proteome) and the kinases regulated substates (phosphoproteome) in EESCC and EDAC. g Pathways based on the selected phospho-substates and kinases, with relevant drugs shown by targets in EESCC (left) and EDAC (right)