Fig. 2

Global phosphoproteome profiling of livers in young and old mice. A PCA of filtered phosphosites in the livers of young and old mice. B FC and P value (two-sample t test) of each filtered phosphosite were plotted in a volcano plot. C Proteins with phosphosites were submitted to Ingenuity Pathway Analysis (IPA) for location prediction. Total: proteins corresponding to the filtered 5,685 sites. Up: proteins corresponding to the 430 upregulated sites. Down: proteins corresponding to the 493 downregulated sites. D Proteins with phosphosites were submitted to IPA for type prediction. Total: proteins corresponding to the filtered 5,685 sites. Up: proteins corresponding to the 430 upregulated sites. Down: proteins corresponding to the 493 downregulated sites