Table 3 Processes and pathways that differentially expressed proteins are involved in based on Reactome pathways
From: Tear proteomics analysis of patient suffered from delayed mustard gas keratopathy
Pathway name | Number of entities found | Number of total entities | Proteins involved (labels) |
|---|---|---|---|
Complement cascade | 5 | 156 | FCN3; IGLV1–51; C4BPA; C4BPB; IGLV10–54 |
Regulation of Complement cascade | 4 | 139 | IGLV1–51; C4BPA; C4BPB; IGLV10–54 |
Innate Immune System | 9 | 1329 | FCN3; IGLV1–51; MUC7; C4BPA; ISG15; C4BPB; MUC4; ARL8A; IGLV10–54 |
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | 2 | 20 | MUC7; MUC4 |
Defective GALNT12 causes colorectal cancer 1 (CRCS1) | 2 | 20 | MUC7; MUC4 |
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | 2 | 21 | MUC7; MUC4 |
Creation of C4 and C2 activators | 3 | 111 | FCN3; IGLV1–51; IGLV10–54 |
Termination of O-glycan biosynthesis | 2 | 28 | MUC7; MUC4 |
Initial triggering of complement | 3 | 120 | FCN3; IGLV1–51; IGLV10–54 |
Immune System | 13 | 2869 | FCN3; IGLV1–51; COL1A2; MUC7; C4BPA; ISG15; C4BPB; MUC4; ARL8A; IGLV10–54 |
Binding and Uptake of Ligands by Scavenger Receptors | 3 | 167 | IGLV1–51; COL1A2; IGLV10–54 |
Diseases of glycosylation | 3 | 202 | MUC7; MUC4; CHST3 |
Dectin-2 family | 2 | 65 | MUC7; MUC4 |
Diseases of metabolism | 4 | 409 | CYP27A1; MUC7; MUC4; CHST3 |
tRNA modification in the nucleus and cytosol | 2 | 70 | CTU2; NSUN2 |
O-linked glycosylation of mucins | 2 | 73 | MUC7; MUC4 |
Chondroitin sulfate/dermatan sulfate metabolism | 2 | 73 | PIP; CHST3 |
Diseases associated with O-glycosylation of proteins | 2 | 78 | MUC7; MUC4 |
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) | 1 | 6 | CYP27A1 |
Cell surface interactions at the vascular wall | 3 | 257 | IGLV1–51; COL1A2; IGLV10–54 |
Classical antibody-mediated complement activation | 2 | 97 | IGLV1–51; IGLV10–54 |
Defective CHST3 causes SEDCJD | 1 | 9 | CHST3 |
FCGR activation | 2 | 103 | IGLV1–51; IGLV10–54 |
Scavenging of heme from plasma | 2 | 106 | IGLV1–51; IGLV10–54 |
Role of LAT2/NTAL/LAB on calcium mobilization | 2 | 107 | IGLV1–51; IGLV10–54 |
SLBP independent Processing of Histone Pre-mRNAs | 1 | 10 | NCBP2 |
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 1 | 11 | NCBP2 |
GP1b-IX-V activation signalling | 1 | 12 | COL1A2 |
Ficolins bind to repetitive carbohydrate structures on the target cell surface | 1 | 12 | FCN3 |