Fig. 4
From: Profiles of transcriptome and metabolic pathways after hypobaric hypoxia exposure
ANGPTL4 and PPARA are key regulators of lipid metabolism following Hypobaric Hypoxia. A The ANGPTL4 and PPARA relative mRNA levels in hypobaric hypoxia rats. ANGPTL4 was up-regulated to the highest level at day 3, while PPARA was down-regulated to the lowest level at day 3. This trend was abated by Fenofibrate, which is consistent with results obtained in HL-7702 cells. Student’s t-test, paired tail, * < 0.05. B Immunohistochemistry of ANGPTL4 in mouse liver tissues. ANGPTL4 was up-regulated due to hypobaric hypoxia treatment and inhibited by Fenofibrate. C Electron microscopic biopsy of rat livers in different groups. Hypobaric hypoxia treatment increases the amount of lipid droplets, while fenofibrate treatment significantly attenuates these changes due to the inhibition of ANGPTL4. D Statistical results for the lipid droplets. Hypobaric hypoxia treated rat livers contain a higher number of lipid droplets. This number decreases following fenofibrate treatment