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  1. Markers of pancreatic cancer invasion were investigated in two clonal populations of the cell line, MiaPaCa-2, Clone #3 (high invasion) and Clone #8 (low invasion) using proteomic profiling of an in vitro model o...

    Authors: Naomi Walsh, Norma O'Donovan, Susan Kennedy, Michael Henry, Paula Meleady, Martin Clynes and Paul Dowling
    Citation: Proteome Science 2009 7:3
    Content type: Research Published on:

  2. TGF-β acts as an antiproliferative factor in normal epithelial cells and at early stages of oncogenesis. However, later in tumor development TGF-β can become tumor promoting through mechanisms including the in...

    Authors: Jennifer J Hill, Tammy-Lynn Tremblay, Christiane Cantin, Maureen O'Connor-McCourt, John F Kelly and Anne EG Lenferink
    Citation: Proteome Science 2009 7:2
    Content type: Research Published on:

  3. Heat stress (HS) and related illnesses are a major concern in military, sports, and fire brigadiers. HS results in physiologic responses of increased temperature, heart rate and sweating. In heat stroke, infla...

    Authors: Ganapathy Rajaseger, Chin Leong Lim, Lee Koon Wui, Padmanabhan Saravanan, Kai Tang, Ponnampalam Gopalakrishnakone, Yap Eric Pen-huat, Jia Lu and Moochhala M Shabbir
    Citation: Proteome Science 2009 7:1
    Content type: Research Published on:

  4. A fundamental pathogenic feature of the fungus Histoplasma capsulatum is its ability to evade innate and adaptive immune defenses. Once ingested by macrophages the organism is faced with several hostile environme...

    Authors: Michael S Winters, Daniel S Spellman, Qilin Chan, Francisco J Gomez, Margarita Hernandez, Brittany Catron, Alan G Smulian, Thomas A Neubert and George S Deepe Jr
    Citation: Proteome Science 2008 6:36
    Content type: Research Published on:

  5. The broad range in growth observed in short prepubertal children receiving the same growth hormone (GH) dose is due to individual variation in GH responsiveness. This study used a pharmaco-proteomic approach i...

    Authors: Gunnel Hellgren, Björn Andersson, Andreas FM Nierop, Jovanna Dahlgren, Ze'ev Hochberg and Kerstin Albertsson-Wikland
    Citation: Proteome Science 2008 6:35
    Content type: Research Published on:

  6. The underlying pathways that drive retinal neurogenesis and synaptogenesis are still relatively poorly understood. Protein expression analysis can provide direct insight into these complex developmental proces...

    Authors: Sorcha Finnegan, Joanne L Robson, Mildred Wylie, Adrienne Healy, Alan W Stitt and William J Curry
    Citation: Proteome Science 2008 6:34
    Content type: Research Published on:

  10. An important step in the proteomics of solid tumors, including breast cancer, consists of efficiently extracting most of proteins in the tumor specimen. For this purpose, Radio-Immunoprecipitation Assay (RIPA)...

    Authors: Lambert CM Ngoka
    Citation: Proteome Science 2008 6:30
    Content type: Research Published on:

  11. Oxidoreductases are enzymes that catalyze many redox reactions in normal and neoplastic cells. Their actions include catalysis of the transformation of free, neutral oxygen gas into oxygen free radicals, super...

    Authors: Lambert CM Ngoka
    Citation: Proteome Science 2008 6:29
    Content type: Research Published on:

  12. Hepcidin is a 25-residue peptide hormone crucial to iron homeostasis. It is essential to measure the concentration of hepcidin in cells, tissues and body fluids to understand its mechanisms and roles in physio...

    Authors: Douglas G Ward, Keith Roberts, Paul Stonelake, Patrick Goon, Cleidiane G Zampronio, Ashley Martin, Philip J Johnson, Tariq Iqbal and Chris Tselepis
    Citation: Proteome Science 2008 6:28
    Content type: Research Published on:

  14. The ProteomeLabâ„¢ PF 2D platform is a relatively new approach to global protein profiling. Herein, it was used for investigation of plasma proteome changes in amyotrophic lateral sclerosis (ALS) patients before...

    Authors: Joshua D Schlautman, Wojciech Rozek, Robert Stetler, R Lee Mosley, Howard E Gendelman and Pawel Ciborowski
    Citation: Proteome Science 2008 6:26
    Content type: Methodology Published on:

  15. Unravelling the serum proteome is the subject of intensified research. In this regard, two-dimensional electrophoresis coupled with MALDI MS analysis is still one of the most commonly used method. Despite some...

    Authors: Maria Stella Ritorto and Jürgen Borlak
    Citation: Proteome Science 2008 6:25
    Content type: Research Published on:

  16. Trypanosoma cruzi, a flagellate protozoan, is the etiological agent of Chagas disease, a chronic illness that causes irreversible damage to heart and digestive tract in humans. Previous 2-DE analyses of T. cruzi

    Authors: Adriana D Magalhães, Sébastien Charneau, Jaime Paba, Rafael AP Guércio, Antonio RL Teixeira, Jaime M Santana, Marcelo V Sousa and Carlos AO Ricart
    Citation: Proteome Science 2008 6:24
    Content type: Research Published on:

  17. The bovine spongiform encephalopathy (BSE) epidemic and the emergence of a new human variant of Creutzfeldt-Jakob Disease (vCJD) have led to profound changes in the production and trade of agricultural goods. ...

    Authors: Sharon LR Simon, Lise Lamoureux, Margot Plews, Michael Stobart, Jillian LeMaistre, Ute Ziegler, Catherine Graham, Stefanie Czub, Martin Groschup and J David Knox
    Citation: Proteome Science 2008 6:23
    Content type: Research Published on:

  20. Acute-phase response involves the simultaneous altered expression of serum proteins in association to inflammation, infection, injury or malignancy. Studies of the acute-phase response usually involve determin...

    Authors: Yeng Chen, Boon-Kiong Lim, Suat-Cheng Peh, Puteri Shafinaz Abdul-Rahman and Onn Haji Hashim
    Citation: Proteome Science 2008 6:20
    Content type: Research Published on:

  21. Colorectal cancer is the second most common cause of cancer related death in the developed world. To date, no blood or stool biomarkers with both high sensitivity and specificity for potentially curable early ...

    Authors: Douglas G Ward, Stephen Nyangoma, Howard Joy, Emma Hamilton, Wenbin Wei, Chris Tselepis, Neil Steven, Michael JO Wakelam, Philip J Johnson, Tariq Ismail and Ashley Martin
    Citation: Proteome Science 2008 6:19
    Content type: Research Published on:

  22. Knockout mice with a deletion of p53 spontaneously develop thymic lymphomas. Two cell lines (SM5 and SM7), established from two independent tumours, exhibited about fifty to seventy two-fold differentially exp...

    Authors: Bent Honoré, Søren Buus and Mogens H Claësson
    Citation: Proteome Science 2008 6:18
    Content type: Research Published on:

  23. Penicillium marneffei is a pathogenic fungus that afflicts immunocompromised individuals having lived or traveled in Southeast Asia. This species is unique in that it is the only dimorphic member of the genus. D...

    Authors: Julie M Chandler, Erin R Treece, Heather R Trenary, Jessica L Brenneman, Tressa J Flickner, Jonathan L Frommelt, Zaw M Oo, Megan M Patterson, William T Rundle, Olga V Valle, Thomas D Kim, Gary R Walker and Chester R Cooper Jr
    Citation: Proteome Science 2008 6:17
    Content type: Research Published on:

  25. Proteomic methodologies increasingly have been applied to the kidney to map the renal cortical proteome and to identify global changes in renal proteins induced by diseases such as diabetes. While progress has...

    Authors: Yingxin Zhao, Larry Denner, Sigmund J Haidacher, Wanda S LeJeune and Ronald G Tilton
    Citation: Proteome Science 2008 6:15
    Content type: Research Published on:

  26. To identify the biochemical changes induced by sleep deprivation at a proteomic level, we compared the hippocampal proteome of rats either after 4 hours of sleep or sleep deprivation obtained by gentle handlin...

    Authors: Jean-Etienne Poirrier, François Guillonneau, Jenny Renaut, Kjell Sergeant, Andre Luxen, Pierre Maquet and Pierre Leprince
    Citation: Proteome Science 2008 6:14
    Content type: Research Published on:

  27. Monocytes can be primed in vitro by lipopolysaccharide (LPS) for release of cytokines, for enhanced killing of cancer cells, and for enhanced release of microbicidal oxygen radicals like superoxide and peroxid...

    Authors: Michael J Pabst, Karen M Pabst, David B Handsman, Sarka Beranova-Giorgianni and Francesco Giorgianni
    Citation: Proteome Science 2008 6:13
    Content type: Research Published on:

  28. Telomerase confers cellular immortality by elongating telomeres, thereby circumventing the Hayflick limit. Extended-life-span cells have been generated by transfection with the human telomerase reverse transcr...

    Authors: Gabriel D Mazzucchelli, Valérie Gabelica, Nicolas Smargiasso, Maximilien Fléron, Wilson Ashimwe, Frédéric Rosu, Marie-Claire De Pauw-Gillet, Jean-François Riou and Edwin De Pauw
    Citation: Proteome Science 2008 6:12
    Content type: Methodology Published on:

  29. Emiliania huxleyi virus 86 (EhV-86) is the type species of the genus Coccolithovirus within the family Phycodnaviridae. The fully sequenced 407,339 bp genome is predicted to encode 473 protein coding sequences (...

    Authors: Michael J Allen, Julie A Howard, Kathryn S Lilley and William H Wilson
    Citation: Proteome Science 2008 6:11
    Content type: Research Published on:

  30. A lack of sensitive and specific biomarkers is a major reason for the high rate of Primary hepatocellular carcinoma (HCC)-related mortality. The aim of this study was to investigate potential proteomic biomarke....

    Authors: Min He, Jian Qin, Rihong Zhai, Xiao Wei, Qi Wang, Minhua Rong, Zhihua Jiang, Yuanjiao Huang and Zhiyong Zhang
    Citation: Proteome Science 2008 6:10
    Content type: Research Published on:

  31. The proteomes of mammalian biological fluids, cells and tissues are complex and composed of proteins with a wide dynamic range. The effective way to overcome the complexity of these proteomes is to combine sev...

    Authors: Jérôme Chenau, Sylvie Michelland, Jonathan Sidibe and Michel Seve
    Citation: Proteome Science 2008 6:9
    Content type: Research Published on:

  32. Parkinson's disease (PD) is the most common neurodegenerative disorder involving the motor system. Although not being the only region involved in PD, affection of the substantia nigra and its projections is re...

    Authors: Cornelius J Werner, Roland Heyny-von Haussen, Gerhard Mall and Sabine Wolf
    Citation: Proteome Science 2008 6:8
    Content type: Research Published on:

  35. Our laboratories have previously reported on the experimental infection of cattle with Mycobacterium avium subsp paratuberculosis (M. paratuberculosis) using an intratonsillar infection model. In addition, we hav...

    Authors: John P Bannantine, Darrell O Bayles, W Ray Waters, Mitchell V Palmer, Judith R Stabel and Michael L Paustian
    Citation: Proteome Science 2008 6:5
    Content type: Research Published on:

  36. An arbitrary set of 96 human proteins was selected and tested to set-up a fully automated protein production strategy, covering all steps from DNA preparation to protein purification and analysis. The target p...

    Authors: Thorsten Kohl, Christian Schmidt, Stefan Wiemann, Annemarie Poustka and Ulrike Korf
    Citation: Proteome Science 2008 6:4
    Content type: Research Published on:

  37. Little is known regarding the molecular pathways that underlie the process of retinal development. The purpose of this study was to identify proteins which may be involved in development of retina. We used a p...

    Authors: Mina Mizukami, Takashi Kanamoto, Nazariy Souchelnytskyi and Yoshiaki Kiuchi
    Citation: Proteome Science 2008 6:3
    Content type: Research Published on:

  38. Trimethylation of the Nε-lysine residues in a protein is one of the most important events of posttranslational modifications. Simple methods for rapid detection and isolation of the Nε-trimethylated protein speci...

    Authors: Ziqian Liang, Ronald PC Wong, Lin Hong Li, Hesheng Jiang, Hao Xiao and Gang Li
    Citation: Proteome Science 2008 6:2
    Content type: Methodology Published on:

  39. Prenatal diagnosis of chromosomal abnormalities by cytogenetic analysis is time-consuming, expensive, and requires highly qualified technicians. Rapid diagnosis of aneuploidies followed by reassurance of women...

    Authors: Alain Mange, Caroline Desmetz, Virginie Bellet, Nicolas Molinari, Thierry Maudelonde and Jerome Solassol
    Citation: Proteome Science 2008 6:1
    Content type: Research Published on:

  40. Many parasitic organisms, eukaryotes as well as bacteria, possess surface antigens with amino acid repeats. Making up the interface between host and pathogen such repetitive proteins may be virulence factors i...

    Authors: Niklaus Fankhauser, Tien-Minh Nguyen-Ha, Joël Adler and Pascal Mäser
    Citation: Proteome Science 2007 5:20
    Content type: Research Published on:

  42. Proteins that migrate through cross-linked polyacrylamide gels (PAGs) under the influence of a constant electric field experience negative factors, such as diffusion and non-specific trapping in the gel matrix...

    Authors: Henghang Tsai, Teck Yew Low, Steve Freeby, Aran Paulus, Kalpana Ramnarayanan, Chung-pui Paul Cheng and Hon-chiu Eastwood Leung
    Citation: Proteome Science 2007 5:18
    Content type: Methodology Published on:

  43. The low concentration and highly hydrophobic nature of proteins in lipid raft samples present significant challenges for the sensitive and accurate proteomic analyses of lipid raft proteins. Elimination of hig...

    Authors: Hongwei Yu, Bassam Wakim, Man Li, Brian Halligan, G Stephen Tint and Shailendra B Patel
    Citation: Proteome Science 2007 5:17
    Content type: Research Published on:

  44. Epithelial ovarian cancer is a devastating disease associated with low survival prognosis mainly because of the lack of early detection markers and the asymptomatic nature of the cancer until late stage. Using...

    Authors: Jean-Philippe Gagné, Chantal Éthier, Pierre Gagné, Geneviève Mercier, Marie-Ève Bonicalzi, Anne-Marie Mes-Masson, Arnaud Droit, Eric Winstall, Maxim Isabelle and Guy G Poirier
    Citation: Proteome Science 2007 5:16
    Content type: Research Published on:

  45. High-Density Lipoprotein (HDL), one of the main plasma lipoproteins, serves as a docking station for proteins involved in inflammation, coagulation, and lipid metabolism.

    Authors: Johannes HM Levels, Boris Bleijlevens, Farhad Rezaee, Johannes MFG Aerts and Joost CM Meijers
    Citation: Proteome Science 2007 5:15
    Content type: Methodology Published on:

  46. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) is a powerful tool for rapidly generating high-throughput protein profiles from a large number of samples. However, ...

    Authors: Toni Whistler, Dominique Rollin and Suzanne D Vernon
    Citation: Proteome Science 2007 5:14
    Content type: Methodology Published on:

  47. Excitatory amino acid carrier 1 (EAAC1) is a glutamate transporter found in neuronal tissues and is extensively expressed in the retina. EAAC1 plays a role in a variety of neural functions, but its biological ...

    Authors: Hideaki Okumichi, Takashi Kanamoto, Nazariy Souchelnytskyi, Seiji Tanimoto, Kohichi Tanaka and Yoshiaki Kiuchi
    Citation: Proteome Science 2007 5:13
    Content type: Research Published on:

  48. Polymorphonuclear neutrophils (PMN) constitute an essential cellular component of innate host defense against microbial invasion and exhibit a wide array of responses both to particulate and soluble stimuli. A...

    Authors: Deepa Jethwaney, Md Rafiqul Islam, Kevin G Leidal, Daniel Beltran-Valero de Bernabe, Kevin P Campbell, William M Nauseef and Bradford W Gibson
    Citation: Proteome Science 2007 5:12
    Content type: Research Published on:

  49. The secretion time course of Bacillus anthracis strain RA3R (pXO1+/pXO2-) during early, mid, and late log phase were investigated under conditions that simulate those encountered in the host. All of the identifie...

    Authors: Alexander Walz, Cesar V Mujer, Joseph P Connolly, Tim Alefantis, Ryan Chafin, Clarissa Dake, Jessica Whittington, Srikanta P Kumar, Akbar S Khan and Vito G DelVecchio
    Citation: Proteome Science 2007 5:11
    Content type: Research Published on:
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