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  2. Acute-phase response involves the simultaneous altered expression of serum proteins in association to inflammation, infection, injury or malignancy. Studies of the acute-phase response usually involve determin...

    Authors: Yeng Chen, Boon-Kiong Lim, Suat-Cheng Peh, Puteri Shafinaz Abdul-Rahman and Onn Haji Hashim
    Citation: Proteome Science 2008 6:20
    Content type: Research Published on:

  3. Colorectal cancer is the second most common cause of cancer related death in the developed world. To date, no blood or stool biomarkers with both high sensitivity and specificity for potentially curable early ...

    Authors: Douglas G Ward, Stephen Nyangoma, Howard Joy, Emma Hamilton, Wenbin Wei, Chris Tselepis, Neil Steven, Michael JO Wakelam, Philip J Johnson, Tariq Ismail and Ashley Martin
    Citation: Proteome Science 2008 6:19
    Content type: Research Published on:

  4. Knockout mice with a deletion of p53 spontaneously develop thymic lymphomas. Two cell lines (SM5 and SM7), established from two independent tumours, exhibited about fifty to seventy two-fold differentially exp...

    Authors: Bent Honoré, Søren Buus and Mogens H Claësson
    Citation: Proteome Science 2008 6:18
    Content type: Research Published on:

  5. Penicillium marneffei is a pathogenic fungus that afflicts immunocompromised individuals having lived or traveled in Southeast Asia. This species is unique in that it is the only dimorphic member of the genus. D...

    Authors: Julie M Chandler, Erin R Treece, Heather R Trenary, Jessica L Brenneman, Tressa J Flickner, Jonathan L Frommelt, Zaw M Oo, Megan M Patterson, William T Rundle, Olga V Valle, Thomas D Kim, Gary R Walker and Chester R Cooper Jr
    Citation: Proteome Science 2008 6:17
    Content type: Research Published on:

  7. Proteomic methodologies increasingly have been applied to the kidney to map the renal cortical proteome and to identify global changes in renal proteins induced by diseases such as diabetes. While progress has...

    Authors: Yingxin Zhao, Larry Denner, Sigmund J Haidacher, Wanda S LeJeune and Ronald G Tilton
    Citation: Proteome Science 2008 6:15
    Content type: Research Published on:

  8. To identify the biochemical changes induced by sleep deprivation at a proteomic level, we compared the hippocampal proteome of rats either after 4 hours of sleep or sleep deprivation obtained by gentle handlin...

    Authors: Jean-Etienne Poirrier, François Guillonneau, Jenny Renaut, Kjell Sergeant, Andre Luxen, Pierre Maquet and Pierre Leprince
    Citation: Proteome Science 2008 6:14
    Content type: Research Published on:

  9. Monocytes can be primed in vitro by lipopolysaccharide (LPS) for release of cytokines, for enhanced killing of cancer cells, and for enhanced release of microbicidal oxygen radicals like superoxide and peroxid...

    Authors: Michael J Pabst, Karen M Pabst, David B Handsman, Sarka Beranova-Giorgianni and Francesco Giorgianni
    Citation: Proteome Science 2008 6:13
    Content type: Research Published on:

  10. Telomerase confers cellular immortality by elongating telomeres, thereby circumventing the Hayflick limit. Extended-life-span cells have been generated by transfection with the human telomerase reverse transcr...

    Authors: Gabriel D Mazzucchelli, Valérie Gabelica, Nicolas Smargiasso, Maximilien Fléron, Wilson Ashimwe, Frédéric Rosu, Marie-Claire De Pauw-Gillet, Jean-François Riou and Edwin De Pauw
    Citation: Proteome Science 2008 6:12
    Content type: Methodology Published on:

  11. Emiliania huxleyi virus 86 (EhV-86) is the type species of the genus Coccolithovirus within the family Phycodnaviridae. The fully sequenced 407,339 bp genome is predicted to encode 473 protein coding sequences (...

    Authors: Michael J Allen, Julie A Howard, Kathryn S Lilley and William H Wilson
    Citation: Proteome Science 2008 6:11
    Content type: Research Published on:

  12. A lack of sensitive and specific biomarkers is a major reason for the high rate of Primary hepatocellular carcinoma (HCC)-related mortality. The aim of this study was to investigate potential proteomic biomarke....

    Authors: Min He, Jian Qin, Rihong Zhai, Xiao Wei, Qi Wang, Minhua Rong, Zhihua Jiang, Yuanjiao Huang and Zhiyong Zhang
    Citation: Proteome Science 2008 6:10
    Content type: Research Published on:

  13. The proteomes of mammalian biological fluids, cells and tissues are complex and composed of proteins with a wide dynamic range. The effective way to overcome the complexity of these proteomes is to combine sev...

    Authors: Jérôme Chenau, Sylvie Michelland, Jonathan Sidibe and Michel Seve
    Citation: Proteome Science 2008 6:9
    Content type: Research Published on:

  14. Parkinson's disease (PD) is the most common neurodegenerative disorder involving the motor system. Although not being the only region involved in PD, affection of the substantia nigra and its projections is re...

    Authors: Cornelius J Werner, Roland Heyny-von Haussen, Gerhard Mall and Sabine Wolf
    Citation: Proteome Science 2008 6:8
    Content type: Research Published on:

  17. Our laboratories have previously reported on the experimental infection of cattle with Mycobacterium avium subsp paratuberculosis (M. paratuberculosis) using an intratonsillar infection model. In addition, we hav...

    Authors: John P Bannantine, Darrell O Bayles, W Ray Waters, Mitchell V Palmer, Judith R Stabel and Michael L Paustian
    Citation: Proteome Science 2008 6:5
    Content type: Research Published on:

  18. An arbitrary set of 96 human proteins was selected and tested to set-up a fully automated protein production strategy, covering all steps from DNA preparation to protein purification and analysis. The target p...

    Authors: Thorsten Kohl, Christian Schmidt, Stefan Wiemann, Annemarie Poustka and Ulrike Korf
    Citation: Proteome Science 2008 6:4
    Content type: Research Published on:

  19. Little is known regarding the molecular pathways that underlie the process of retinal development. The purpose of this study was to identify proteins which may be involved in development of retina. We used a p...

    Authors: Mina Mizukami, Takashi Kanamoto, Nazariy Souchelnytskyi and Yoshiaki Kiuchi
    Citation: Proteome Science 2008 6:3
    Content type: Research Published on:

  20. Trimethylation of the Nε-lysine residues in a protein is one of the most important events of posttranslational modifications. Simple methods for rapid detection and isolation of the Nε-trimethylated protein speci...

    Authors: Ziqian Liang, Ronald PC Wong, Lin Hong Li, Hesheng Jiang, Hao Xiao and Gang Li
    Citation: Proteome Science 2008 6:2
    Content type: Methodology Published on:

  21. Prenatal diagnosis of chromosomal abnormalities by cytogenetic analysis is time-consuming, expensive, and requires highly qualified technicians. Rapid diagnosis of aneuploidies followed by reassurance of women...

    Authors: Alain Mange, Caroline Desmetz, Virginie Bellet, Nicolas Molinari, Thierry Maudelonde and Jerome Solassol
    Citation: Proteome Science 2008 6:1
    Content type: Research Published on:

  22. Many parasitic organisms, eukaryotes as well as bacteria, possess surface antigens with amino acid repeats. Making up the interface between host and pathogen such repetitive proteins may be virulence factors i...

    Authors: Niklaus Fankhauser, Tien-Minh Nguyen-Ha, Joël Adler and Pascal Mäser
    Citation: Proteome Science 2007 5:20
    Content type: Research Published on:

  24. Proteins that migrate through cross-linked polyacrylamide gels (PAGs) under the influence of a constant electric field experience negative factors, such as diffusion and non-specific trapping in the gel matrix...

    Authors: Henghang Tsai, Teck Yew Low, Steve Freeby, Aran Paulus, Kalpana Ramnarayanan, Chung-pui Paul Cheng and Hon-chiu Eastwood Leung
    Citation: Proteome Science 2007 5:18
    Content type: Methodology Published on:

  25. The low concentration and highly hydrophobic nature of proteins in lipid raft samples present significant challenges for the sensitive and accurate proteomic analyses of lipid raft proteins. Elimination of hig...

    Authors: Hongwei Yu, Bassam Wakim, Man Li, Brian Halligan, G Stephen Tint and Shailendra B Patel
    Citation: Proteome Science 2007 5:17
    Content type: Research Published on:

  26. Epithelial ovarian cancer is a devastating disease associated with low survival prognosis mainly because of the lack of early detection markers and the asymptomatic nature of the cancer until late stage. Using...

    Authors: Jean-Philippe Gagné, Chantal Éthier, Pierre Gagné, Geneviève Mercier, Marie-Ève Bonicalzi, Anne-Marie Mes-Masson, Arnaud Droit, Eric Winstall, Maxim Isabelle and Guy G Poirier
    Citation: Proteome Science 2007 5:16
    Content type: Research Published on:

  27. High-Density Lipoprotein (HDL), one of the main plasma lipoproteins, serves as a docking station for proteins involved in inflammation, coagulation, and lipid metabolism.

    Authors: Johannes HM Levels, Boris Bleijlevens, Farhad Rezaee, Johannes MFG Aerts and Joost CM Meijers
    Citation: Proteome Science 2007 5:15
    Content type: Methodology Published on:

  28. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) is a powerful tool for rapidly generating high-throughput protein profiles from a large number of samples. However, ...

    Authors: Toni Whistler, Dominique Rollin and Suzanne D Vernon
    Citation: Proteome Science 2007 5:14
    Content type: Methodology Published on:

  29. Excitatory amino acid carrier 1 (EAAC1) is a glutamate transporter found in neuronal tissues and is extensively expressed in the retina. EAAC1 plays a role in a variety of neural functions, but its biological ...

    Authors: Hideaki Okumichi, Takashi Kanamoto, Nazariy Souchelnytskyi, Seiji Tanimoto, Kohichi Tanaka and Yoshiaki Kiuchi
    Citation: Proteome Science 2007 5:13
    Content type: Research Published on:

  30. Polymorphonuclear neutrophils (PMN) constitute an essential cellular component of innate host defense against microbial invasion and exhibit a wide array of responses both to particulate and soluble stimuli. A...

    Authors: Deepa Jethwaney, Md Rafiqul Islam, Kevin G Leidal, Daniel Beltran-Valero de Bernabe, Kevin P Campbell, William M Nauseef and Bradford W Gibson
    Citation: Proteome Science 2007 5:12
    Content type: Research Published on:

  31. The secretion time course of Bacillus anthracis strain RA3R (pXO1+/pXO2-) during early, mid, and late log phase were investigated under conditions that simulate those encountered in the host. All of the identifie...

    Authors: Alexander Walz, Cesar V Mujer, Joseph P Connolly, Tim Alefantis, Ryan Chafin, Clarissa Dake, Jessica Whittington, Srikanta P Kumar, Akbar S Khan and Vito G DelVecchio
    Citation: Proteome Science 2007 5:11
    Content type: Research Published on:

  35. The adaptive immune response requires waves of T-cell clonal expansion on contact with pathogen and elimination after clearance of the source of antigen. However, lifelong persistent infections with common vir...

    Authors: Dawn J Mazzatti, Graham Pawelec, Robin Longdin, Jonathan R Powell and Rosalyn J Forsey
    Citation: Proteome Science 2007 5:7
    Content type: Research Published on:

  36. The aromatic amine 4-aminobiphenyl (4-ABP) is an environmental and occupational contaminant known to be a major etiological agent of human bladder cancer. 4-ABP metabolites are able to form DNA adducts that ma...

    Authors: Roberta Pastorelli, Federica Saletta, Donatella Carpi, Roberta Campagna, Carlo dell'Osta, Silvia Schiarea, Paolo Vineis, Luisa Airoldi and Giuseppe Matullo
    Citation: Proteome Science 2007 5:6
    Content type: Research Published on:

  37. To identify the pattern of protein expression in the retina from a patient with Leber's Congenital Amaurosis (LCA) secondary to a mutation in the AIPL1 gene. The retina from one eye of a patient with LCA and 7 co...

    Authors: Henrik Vorum, Morten Østergaard, Greg E Rice, Bent Honoré and Toke Bek
    Citation: Proteome Science 2007 5:5
    Content type: Research Published on:

  38. Proteomics continues to play a critical role in post-genomic science as continued advances in mass spectrometry and analytical chemistry support the separation and identification of increasing numbers of pepti...

    Authors: Jennifer A Siepen, Neil Swainston, Andrew R Jones, Sarah R Hart, Henning Hermjakob, Philip Jones and Simon J Hubbard
    Citation: Proteome Science 2007 5:4
    Content type: Research Published on:

  39. Tandem mass spectrometry followed by database search is currently the predominant technology for peptide sequencing in shotgun proteomics experiments. Most methods compare experimentally observed spectra to th...

    Authors: Jian Liu, Alexander W Bell, John JM Bergeron, Corey M Yanofsky, Brian Carrillo, Christian EH Beaudrie and Robert E Kearney
    Citation: Proteome Science 2007 5:3
    Content type: Research Published on:

  40. Urine consists of a complex mixture of peptides and proteins and therefore is an interesting source of biomarkers. Because of its high throughput capacity SELDI-TOF-MS is a proteomics technology frequently use...

    Authors: Han Roelofsen, Gloria Alvarez-Llamas, Marianne Schepers, Karloes Landman and Roel J Vonk
    Citation: Proteome Science 2007 5:2
    Content type: Methodology Published on:

  41. Ischemia-reperfusion (I/R) causes a dramatic reprogramming of cell metabolism during liver transplantation and can be linked to an alteration of the phosphorylation level of several cellular proteins. Over the...

    Authors: Anouk Emadali, Peter P Metrakos, Fariba Kalantari, Tarek Boutros, Daniel Boismenu and Eric Chevet
    Citation: Proteome Science 2007 5:1
    Content type: Research Published on:

  42. Opiate addiction reflects plastic changes that endurably alter synaptic transmission within relevant neuronal circuits. The biochemical mechanisms of these adaptations remain largely unknown and proteomics-bas...

    Authors: Jérémie Neasta, Sandrine Uttenweiler-Joseph, Karima Chaoui, Bernard Monsarrat, Jean-Claude Meunier and Lionel Moulédous
    Citation: Proteome Science 2006 4:23
    Content type: Research Published on:

  43. The aim of the study was to optimize protocols for finding and identifying serum proteins that are differentially expressed in persons with normal glucose tolerance (NGT) compared to individuals with type 2 di...

    Authors: Tea Sundsten, Michael Eberhardson, Michael Göransson and Peter Bergsten
    Citation: Proteome Science 2006 4:22
    Content type: Research Published on:

  44. The antibody microarray technique is a newly emerging proteomics tool for differential protein expression analyses that uses fluorescent dyes Cy 3 and Cy 5. Environmental factors, such as light exposure, can a...

    Authors: Qiang Gu, Thamil Mani Sivanandam and Caroline Aehyun Kim
    Citation: Proteome Science 2006 4:21
    Content type: Methodology Published on:

  45. Surface-Enhanced Laser Desorption/Ionization – Time Of Flight (SELDI-TOF) has been proposed as new approach for blood biomarker discovery. However, results obtained so far have been often disappointing as this...

    Authors: Stéphane Roche, Laurent Tiers, Monique Provansal, Marie-Thérèse Piva and Sylvain Lehmann
    Citation: Proteome Science 2006 4:20
    Content type: Methodology Published on:

  46. High cell density cultivations were performed under identical conditions for two Bacillus megaterium strains (MS941 and WH320), both carrying a heterologous dextransucrase (dsrS) gene under the control of the xyl...

    Authors: Wei Wang, Rajan Hollmann and Wolf-Dieter Deckwer
    Citation: Proteome Science 2006 4:19
    Content type: Research Published on:

  47. The elemental composition of peptides results in formation of distinct, equidistantly spaced clusters across the mass range. The property of peptide mass clustering is used to calibrate peptide mass lists, to ...

    Authors: Witold E Wolski, Malcolm Farrow, Anne-Katrin Emde, Hans Lehrach, Maciej Lalowski and Knut Reinert
    Citation: Proteome Science 2006 4:18
    Content type: Methodology Published on:

  48. Proteomics may help to detect subtle pollution-related changes, such as responses to mixture pollution at low concentrations, where clear signs of toxicity are absent. The challenges associated with the analys...

    Authors: Tiphaine Monsinjon, Odd Ketil Andersen, François Leboulenger and Thomas Knigge
    Citation: Proteome Science 2006 4:17
    Content type: Methodology Published on:

  49. Blood monocytes play a central role in regulating host inflammatory processes through chemotaxis, phagocytosis, and cytokine production. However, the molecular details underlying these diverse functions are no...

    Authors: Ming Jin, Philip T Diaz, Tran Bourgeois, Charis Eng, Clay B Marsh and Haifeng M Wu
    Citation: Proteome Science 2006 4:16
    Content type: Research Published on:

  50. Characterization of protein modification by phosphorylation is one of the major tasks that have to be accomplished in the post-genomic era. Phosphorylation is a key reversible modification occurring mainly on ...

    Authors: Frédéric Delom and Eric Chevet
    Citation: Proteome Science 2006 4:15
    Content type: Review Published on:
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