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  1. Despite extensive research on hepatic cells precursors and their differentiated states, much remains to be learned about the mechanism underlying the self-renewal and differentiation.

    Authors: Claudia Montaldo, Carmine Mancone, Alice Conigliaro, Angela Maria Cozzolino, Valeria de Nonno and Marco Tripodi

    Citation: Proteome Science 2014 12:15

    Content type: Research

    Published on:

  2. The length of time that a protein remains available to perform its function is significantly influenced by its turnover rate. Knowing the turnover rate of proteins involved in different processes is important ...

    Authors: Marie-Laure A Sauer, Bing Xu and Fedora Sutton

    Citation: Proteome Science 2014 12:14

    Content type: Methodology

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  3. Scientists have injected endotoxin into animals to investigate and understand various pathologies and novel therapies for several decades. Recent observations have shown that there is selective susceptibility to

    Authors: Saul Chemonges, John-Paul Tung and John F Fraser

    Citation: Proteome Science 2014 12:12

    Content type: Review

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  4. Proteomic analysis was performed in post-nuclear supernatant (PNS) and Percoll-purified membranes (PM) prepared from fore brain cortex of rats exposed to increasing doses of morphine (10–50 mg/kg) for 10 days.

    Authors: Hana Ujcikova, Adam Eckhardt, Dmytro Kagan, Lenka Roubalova and Petr Svoboda

    Citation: Proteome Science 2014 12:11

    Content type: Research

    Published on:

  5. Blast wounds often involve diverse tissue types and require substantial time and treatment for appropriate healing. Some of these subsequent wounds become colonized with bacteria requiring a better understandi...

    Authors: Brett A Chromy, Angela Eldridge, Jonathan A Forsberg, Trevor S Brown, Benjamin C Kirkup, Eric Elster and Paul Luciw

    Citation: Proteome Science 2014 12:10

    Content type: Methodology

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  6. Certain wheat gluten proteins form large protein polymers that are extractable in 0.5% SDS only after sonication. Although there is a strong relationship between the amounts of these polymers in the flour and ...

    Authors: William H Vensel, Charlene K Tanaka and Susan B Altenbach

    Citation: Proteome Science 2014 12:8

    Content type: Research

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  7. Apple, an invaluable fruit crop worldwide, is often prone to infection by pathogenic fungi. Identification of potentially resistance-conferring apple proteins is one of the most important aims for studying app...

    Authors: Miaomiao Li, Jianhua Xu, Zonghao Qiu, Juan Zhang, Fengwang Ma and Junke Zhang

    Citation: Proteome Science 2014 12:7

    Content type: Research

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  8. Fast Fixation is necessary to study real-time protein-protein interactions under physiological conditions. Fast formaldehyde cross-linking can fix transient and weak protein interactions, thereby reducing the ...

    Authors: Lisi Zhu, Menglin Li, Lilong Wei, Xuejiao Liu, Jianrui Yin and Youhe Gao

    Citation: Proteome Science 2014 12:6

    Content type: Research

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  9. With the promise of disease modifying treatments, there is a need for more specific diagnosis and prognosis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Plasma biomarkers are likely to be u...

    Authors: Fei Song, Anne Poljak, Nicole A Kochan, Mark Raftery, Henry Brodaty, George A Smythe and Perminder S Sachdev

    Citation: Proteome Science 2014 12:5

    Content type: Research

    Published on:

  10. The complexity of protein glycosylation makes it difficult to characterize glycosylation patterns on a proteomic scale. In this study, we developed an integrated strategy for comparatively analyzing N-glycosyl...

    Authors: Ji Wang, Chuang Zhou, Wei Zhang, Jun Yao, Haojie Lu, Qiongzhu Dong, Haijun Zhou and Lunxiu Qin

    Citation: Proteome Science 2014 12:4

    Content type: Research

    Published on:

  11. A limiting factor in performing proteomics analysis on cancerous cells is the difficulty in obtaining sufficient amounts of starting material. Cell lines can be used as a simplified model system for studying c...

    Authors: Saiful Anuar Karsani, Nor Afiza Saihen, Rosnah Binti Zain, Sok-Ching Cheong and Mariati Abdul Rahman

    Citation: Proteome Science 2014 12:3

    Content type: Research

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  12. Profiling technologies allow the simultaneous measurement and comparison of thousands of cell components without prior knowledge of their identity. In the present study, we used two-dimensional gel electrophor...

    Authors: Sarah Zanon Agapito-Tenfen, Miguel Pedro Guerra, Odd-Gunnar Wikmark and Rubens Onofre Nodari

    Citation: Proteome Science 2013 11:46

    Content type: Research

    Published on:

  13. Pathogenic mycobacteria are important agents causing human disease. Mycobacterium avium subsp. hominissuis (M. avium) is a species of recalcitrant environmental pathogen. The bacterium forms robust biofilms that ...

    Authors: Michael McNamara, Shin-Cheng Tzeng, Claudia Maier, Martin Wu and Luiz E Bermudez

    Citation: Proteome Science 2013 11:45

    Content type: Research

    Published on:

  14. Many computational approaches have been developed to detect protein complexes from protein-protein interaction (PPI) networks. However, these PPI networks are always built from high-throughput experiments. The...

    Authors: Bo Xu, Hongfei Lin, Kavishwar B Wagholikar, Zhihao Yang and Hongfang Liu

    Citation: Proteome Science 2013 11(Suppl 1):S21

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  15. Protein interaction networks (PINs) are known to be useful to detect protein complexes. However, most available PINs are static, which cannot reflect the dynamic changes in real networks. At present, some rese...

    Authors: Qianghua Xiao, Jianxin Wang, Xiaoqing Peng and Fang-Xiang Wu

    Citation: Proteome Science 2013 11(Suppl 1):S20

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  16. Proteins are essential biological molecules which play vital roles in nearly all biological processes. It is the tertiary structure of a protein that determines its functions. Therefore the prediction of a pro...

    Authors: Jyh-Jong Tsay and Shih-Chieh Su

    Citation: Proteome Science 2013 11(Suppl 1):S19

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  17. Recently, large data sets of protein-protein interactions (PPI) which can be modeled as PPI networks are generated through high-throughput methods. And locally dense regions in PPI networks are very likely to ...

    Authors: Shuliang Wang and Fang Wu

    Citation: Proteome Science 2013 11(Suppl 1):S18

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  18. Biomedical extraction based on supervised machine learning still faces the problem that a limited labeled dataset does not saturate the learning method. Many supervised learning algorithms for bio-event extrac...

    Authors: Jian Wang, Qian Xu, Hongfei Lin, Zhihao Yang and Yanpeng Li

    Citation: Proteome Science 2013 11(Suppl 1):S17

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  19. Tandem affinity purification coupled with mass-spectrometry (TAP/MS) analysis is a popular method for the identification of novel endogenous protein-protein interactions (PPIs) in large-scale. Computational an...

    Authors: Xiaoyun Sun, Pengyu Hong, Meghana Kulkarni, Young Kwon and Norbert Perrimon

    Citation: Proteome Science 2013 11(Suppl 1):S16

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  20. The immune system must detect a wide variety of microbial pathogens, such as viruses, bacteria, fungi and parasitic worms, to protect the host against disease. Antigenic peptides displayed by MHC II (class II ...

    Authors: Wen-Jun Shen, Shaohong Zhang and Hau-San Wong

    Citation: Proteome Science 2013 11(Suppl 1):S15

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  21. Phosphorylation site assignment of high throughput tandem mass spectrometry (LC-MS/MS) data is one of the most common and critical aspects of phosphoproteomics. Correctly assigning phosphorylated residues help...

    Authors: Fahad Saeed, Trairak Pisitkun, Jason D Hoffert, Sara Rashidian, Guanghui Wang, Marjan Gucek and Mark A Knepper

    Citation: Proteome Science 2013 11(Suppl 1):S14

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  22. Differences in sample collection, biomolecule extraction, and instrument variability introduce bias to data generated by liquid chromatography coupled with mass spectrometry (LC-MS). Normalization is used to a...

    Authors: Mohammad R Nezami Ranjbar, Yi Zhao, Mahlet G Tadesse, Yue Wang and Habtom W Ressom

    Citation: Proteome Science 2013 11(Suppl 1):S13

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  23. Many problems in protein modeling require obtaining a discrete representation of the protein conformational space as an ensemble of conformations. In ab-initio structure prediction, in particular, where the go...

    Authors: Brian S Olson and Amarda Shehu

    Citation: Proteome Science 2013 11(Suppl 1):S12

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  24. Prediction and analysis of protein-protein interactions (PPI) and specifically types of PPIs is an important problem in life science research because of the fundamental roles of PPIs in many biological process...

    Authors: Mina Maleki, Gokul Vasudev and Luis Rueda

    Citation: Proteome Science 2013 11(Suppl 1):S11

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  25. The sequence database searching has been the dominant method for peptide identification, in which a large number of peptide spectra generated from LC/MS/MS experiments are searched using a search engine agains...

    Authors: Xijun Liang, Zhonghang Xia, Xinnan Niu, Andrew J Link, Liping Pang, Fang-Xiang Wu and Hongwei Zhang

    Citation: Proteome Science 2013 11(Suppl 1):S10

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  26. To understand the function of protein complexes and their association with biological processes, a lot of studies have been done towards analyzing the protein-protein interaction (PPI) networks. However, the a...

    Authors: Chengwei Lei, Saleh Tamim, Alexander JR Bishop and Jianhua Ruan

    Citation: Proteome Science 2013 11(Suppl 1):S9

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  27. Discovering sequence patterns with variation can unveil functions of a protein family that are important for drug discovery. Exploring protein families using existing methods such as multiple sequence alignmen...

    Authors: En-Shiun Annie Lee and Andrew KC Wong

    Citation: Proteome Science 2013 11(Suppl 1):S8

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  28. Membrane proteins perform essential roles in diverse cellular functions and are regarded as major pharmaceutical targets. The significance of membrane proteins has led to the developing dozens of resources rel...

    Authors: Min-Sung Kim and Gwan-Su Yi

    Citation: Proteome Science 2013 11(Suppl 1):S7

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  29. Elucidating the three-dimensional structure of a higher-order molecular assembly formed by interacting molecular units, a problem commonly known as docking, is central to unraveling the molecular basis of cell...

    Authors: Irina Hashmi and Amarda Shehu

    Citation: Proteome Science 2013 11(Suppl 1):S6

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  30. β-turns are secondary structure type that have essential role in molecular recognition, protein folding, and stability. They are found to be the most common type of non-repetitive structures since 25% of amino ....

    Authors: Murtada Khalafallah Elbashir, Jianxin Wang, Fang-Xiang Wu and Lusheng Wang

    Citation: Proteome Science 2013 11(Suppl 1):S5

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  31. Independent of the approach used, the ability to correctly interpret tandem MS data depends on the quality of the original spectra. Even in the case of the highest quality spectra, the majority of spectral pea...

    Authors: James P Cleveland and John R Rose

    Citation: Proteome Science 2013 11(Suppl 1):S4

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  32. Protein-protein interactions (PPIs) play a key role in understanding the mechanisms of cellular processes. The availability of interactome data has catalyzed the development of computational approaches to eluc...

    Authors: Young-Rae Cho, Marco Mina, Yanxin Lu, Nayoung Kwon and Pietro H Guzzi

    Citation: Proteome Science 2013 11(Suppl 1):S3

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  33. Detecting protein complexes in protein-protein interaction (PPI) networks plays an important role in improving our understanding of the dynamic of cellular organisation. However, protein interaction data gener...

    Authors: Bingjing Cai, Haiying Wang, Huiru Zheng and Hui Wang

    Citation: Proteome Science 2013 11(Suppl 1):S2

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  34. Today large scale genome sequencing technologies are uncovering an increasing amount of new genes and proteins, which remain uncharacterized. Experimental procedures for protein function prediction are low thr...

    Authors: Alfredo Benso, Stefano Di Carlo, Hafeez ur Rehman, Gianfranco Politano, Alessandro Savino and Prashanth Suravajhala

    Citation: Proteome Science 2013 11(Suppl 1):S1

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  35. Aeromonas salmonicida subsp. salmonicida, the etiologic agent of furunculosis, is a major pathogen of fisheries worldwide. Despite the identification of several virulence factors the pathogenesis is still poorly...

    Authors: Philippe Vanden Bergh, Manfred Heller, Sophie Braga-Lagache and Joachim Frey

    Citation: Proteome Science 2013 11:44

    Content type: Research

    Published on:

  36. Osteoarthritis (OA) is a destructive joint disease and there are no known biomarkers available for an early diagnosis. To identify potential disease biomarkers and gain further insight into the disease mechani...

    Authors: Johan Stenberg, Ulla Rüetschi, Eva Skiöldebrand, Johan Kärrholm and Anders Lindahl

    Citation: Proteome Science 2013 11:43

    Content type: Research

    Published on:

  37. Aeromonas salmonicida subsp. salmonicida, the etiologic agent of furunculosis, is a major pathogen of fisheries worldwide. Several virulence factors have been described, but the type-three secretion system (T3SS...

    Authors: Philippe Vanden Bergh, Manfred Heller, Sophie Braga-Lagache and Joachim Frey

    Citation: Proteome Science 2013 11:42

    Content type: Research

    Published on:

  38. Fusarium wilt of banana is one of the most destructive diseases in the world. This disease has caused heavy losses in major banana production areas. Except for molecular breeding methods based on plant defense...

    Authors: Xingshen Li, Tingting Bai, Yunfeng Li, Xiaolei Ruan and Huaping Li

    Citation: Proteome Science 2013 11:41

    Content type: Research

    Published on:

  39. Post treatment minimal residual disease (MRD) determination contributes to impending relapse prediction, chemotherapy response and clinical outcomes assessment, guiding clinicians to develop reasonable and eff...

    Authors: Ju Bai, Aili He, Wanggang Zhang, Chen Huang, Juan Yang, Yun Yang, Jianli Wang and Yang Zhang

    Citation: Proteome Science 2013 11:39

    Content type: Research

    Published on:

  40. Cell surface glycoprotein sialylation is one of the most ubiquitous glycan modifications found on higher eukaryotes. The surface sialylation pattern of cells is influenced by the cellular environment but also ...

    Authors: Ville I Parviainen, Sakari Joenväärä, Niina Tohmola and Risto Renkonen

    Citation: Proteome Science 2013 11:38

    Content type: Research

    Published on:

  41. Liver perfusates exhibit theoretical advantages regarding the discovery of disease biomarkers because they contain proteins that readily enter the blood-stream, and perfusion preserves the disease state in its...

    Authors: Yang Zhang, Menglin Li, Lilong Wei, Lisi Zhu, Siqi Hu, Shuzhen Wu, Sucan Ma and Youhe Gao

    Citation: Proteome Science 2013 11:37

    Content type: Research

    Published on:

  42. Two-dimensional gel electrophoresis (2DE) is one of the most popular methods in proteomics. Currently, most 2DE experiments are performed using immobilized pH gradient (IPG) in the first dimension; however, so...

    Authors: Rimantas Slibinskas, Raimundas Ražanskas, Rūta Zinkevičiūtė and Evaldas Čiplys

    Citation: Proteome Science 2013 11:36

    Content type: Research

    Published on:

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