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  1. Hepatitis C virus (HCV) poses a growing threat to global health as it often leads to serious liver diseases and is one of the primary causes for liver transplantation. Currently, no vaccines are available to p...

    Authors: Ragunath Singaravelu, David R Blais, Craig S McKay and John Paul Pezacki
    Citation: Proteome Science 2010 8:5
  2. As part of a clinical proteomics program focused on diabetes and its complications we are looking for new and better protein biomarkers for diabetic nephropathy. The search for new and better biomarkers for di...

    Authors: Anne Julie Overgaard, Henning Gram Hansen, Maria Lajer, Lykke Pedersen, Lise Tarnow, Peter Rossing, James N McGuire and Flemming Pociot
    Citation: Proteome Science 2010 8:4
  3. Although mechanical ventilation (MV) is a major supportive therapy for patients with acute respiratory distress syndrome, it may result in side effects including lung injury. In this study we hypothesize that ...

    Authors: Adrian Doroszko, Thomas S Hurst, Dorota Polewicz, Jolanta Sawicka, Justyna Fert-Bober, David H Johnson and Grzegorz Sawicki
    Citation: Proteome Science 2010 8:3
  4. Pituitary adenomas, the third most common intracranial tumor, comprise nearly 16.7% of intracranial neoplasm and 25%-44% of pituitary adenomas are prolactinomas. Prolactinoma represents a complex heterogeneous...

    Authors: Yingchao Liu, Jinsong Wu, Guoquan Yan, Ruiping Hou, Dongxiao Zhuang, Luping Chen, Qi Pang and Jianhong Zhu
    Citation: Proteome Science 2010 8:2
  5. Insects have an efficient self-defense system that is based on innate immunity. Recent findings have disclosed many parallels between human and insect innate immunity, and simultaneously fine differences in th...

    Authors: Alice Masova, Miloslav Sanda, Jiri Jiracek and Irena Selicharova
    Citation: Proteome Science 2010 8:1
  6. Although 70% (or 2/3) partial hepatectomy (PH) is the most studied model for liver regeneration, the hepatic protein expression profile associated with lower volume liver resection (such as 50% PH) has not yet...

    Authors: Hongcui Cao, Jiong Yu, Wei Xu, Xiaofei Jia, Jinfeng Yang, Qiaoling Pan, Qiyi Zhang, Guoping Sheng, Jun Li, Xiaoping Pan, Yingjie Wang and Lanjuan Li
    Citation: Proteome Science 2009 7:48
  7. Plant Growth Promoting Rhizobacteria (PGPR), Pseudomonas fluorescens strain KH-1 was found to exhibit plant growth promotional activity in rice under both in-vitro and in-vivo conditions. But the mechanism underl...

    Authors: Saveetha Kandasamy, Karthiba Loganathan, Raveendran Muthuraj, Saravanakumar Duraisamy, Suresh Seetharaman, Raguchander Thiruvengadam, Balasubramanian Ponnusamy and Samiyappan Ramasamy
    Citation: Proteome Science 2009 7:47
  8. Progression through the cell cycle is accompanied by tightly controlled regulation of transcription. On one hand, a subset of genes is expressed in a cell cycle-dependent manner. On the other hand, a general i...

    Authors: WWM Pim Pijnappel, Annemieke Kolkman, Marijke PA Baltissen, Albert JR Heck and HT Marc Timmers
    Citation: Proteome Science 2009 7:46
  9. Mycoplasma hyopneumoniae is a highly infectious swine pathogen and is the causative agent of enzootic pneumonia (EP). Following the previous report of a proteomic survey of the pathogenic 7448 strain of swine pa...

    Authors: Paulo M Pinto, Cátia S Klein, Arnaldo Zaha and Henrique B Ferreira
    Citation: Proteome Science 2009 7:45
  10. While the larval-juvenile transition (metamorphosis) in the spionid polychaete Pseudopolydora vexillosa involves gradual morphological changes and does not require substantial development of juvenile organs, the ...

    Authors: Flora SY Mok, Vengatesen Thiyagarajan and Pei-Yuan Qian
    Citation: Proteome Science 2009 7:44
  11. B-cell lymphomas are thought to reflect different stages of B-cell maturation. Based on cytogenetics and molecular markers, mantle cell lymphoma (MCL) is presumed to derive predominantly from naïve, pre-germin...

    Authors: Henrik Stranneheim, Lukas M Orre, Janne Lehtiö and Jenny Flygare
    Citation: Proteome Science 2009 7:43
  12. Under conditions of salt stress, plants respond by initiating phosphorylation cascades. Many key phosphorylation events occur at the membrane. However, to date only limited sites have been identified that are ...

    Authors: Jue-Liang Hsu, Lan-Yu Wang, Shu-Ying Wang, Ching-Huang Lin, Kuo-Chieh Ho, Fong-Ku Shi and Ing-Feng Chang
    Citation: Proteome Science 2009 7:42
  13. Dorsal root ganglion (DRG) neurons are primary sensory neurons that conduct neuronal impulses related to pain, touch and temperature senses. Plasma membrane (PM) of DRG cells plays important roles in their fun...

    Authors: Xia Xiong, Sha Huang, Hai Zhang, Jianjun Li, Jianying Shen, Jixian Xiong, Yong Lin, Liping Jiang, Xianchun Wang and Sonping Liang
    Citation: Proteome Science 2009 7:41
  14. The broad range in growth observed in response to growth hormone (GH) treatment is mainly caused by individual variations in both GH secretion and GH sensitivity. Individual GH responsiveness can be estimated ...

    Authors: Björn Andersson, Gunnel Hellgren, Andreas FM Nierop, Ze'ev Hochberg and Kerstin Albertsson-Wikland
    Citation: Proteome Science 2009 7:40
  15. Hepatitis E, caused by the hepatitis E virus (HEV), is endemic to developing countries where it manifests as waterborne outbreaks and sporadic cases. Though generally self-limited with a low mortality rate, so...

    Authors: Shikha Taneja, Somdutta Sen, Vijay K Gupta, Rakesh Aggarwal and Shahid Jameel
    Citation: Proteome Science 2009 7:39
  16. Two-dimensional gel electrophoresis (2-DE) is a powerful method to study protein expression and function in living organisms and diseases. This technique, however, has not been applied to avian bursa of Fabric...

    Authors: Yongping Wu, Jiyong Zhou, Xin Zhang, Xiaojuan Zheng, Xuetao Jiang, Lixue Shi, Wei Yin and Junhua Wang
    Citation: Proteome Science 2009 7:38
  17. Acinetobacter baumannii is a nosocomial pathogen that has been associated with outbreak infections in hospitals. Despite increasing awareness about this bacterium, its proteome remains poorly characterised, howe...

    Authors: Nelson C Soares, Maria P Cabral, José R Parreira, Carmen Gayoso, Maria J Barba and Germán Bou
    Citation: Proteome Science 2009 7:37
  18. Decoding of the liver proteome is subject of intense research, but hampered by methodological constraints. We recently developed an improved protocol for studying rat liver proteins based on 2-DE-MALDI-TOF-MS ...

    Authors: Giuseppe Gazzana and Jürgen Borlak
    Citation: Proteome Science 2009 7:35
  19. Only a minority of patients with advanced non-small cell lung cancer (NSCLC) benefit from chemotherapy. Serum peptide profiling of NSCLC patients was performed to investigate patterns associated with treatment...

    Authors: Johannes Voortman, Thang V Pham, Jaco C Knol, Giuseppe Giaccone and Connie R Jimenez
    Citation: Proteome Science 2009 7:34
  20. The present study examined the changes in protein expression in Spirulina platensis upon exposure to high temperature, with the changes in expression analyzed at the subcellular level. In addition, the transcript...

    Authors: Apiradee Hongsthong, Matura Sirijuntarut, Rayakorn Yutthanasirikul, Jittisak Senachak, Pavinee Kurdrid, Supapon Cheevadhanarak and Morakot Tanticharoen
    Citation: Proteome Science 2009 7:33
  21. Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ...

    Authors: Gisele G Tomazella, Idalete da Silva, Helen J Laure, José C Rosa, Roger Chammas, Harald G Wiker, Gustavo A de Souza and Lewis J Greene
    Citation: Proteome Science 2009 7:32
  22. Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic birth defect. Congenital heart defects (CHD) are seen in 40% of DS children, and >50% of all atrioventricular ca...

    Authors: Frédéric Delom, Emma Burt, Alex Hoischen, Joris Veltman, Jürgen Groet, Finbarr E Cotter and Dean Nizetic
    Citation: Proteome Science 2009 7:31
  23. Enterobacter sp. YSU is resistant to several different heavy metal salts, including selenite. A previous study using M-9 minimal medium showed that when the selenite concentration was 100,000 times higher than t...

    Authors: Ashley Jasenec, Nathaniel Barasa, Samatha Kulkarni, Nabeel Shaik, Swarnalatha Moparthi, Venkataramana Konda and Jonathan Caguiat
    Citation: Proteome Science 2009 7:30
  24. Infection with high-risk type human papilloma viruses (HPVs) is associated with cervical carcinomas and with a subset of head and neck squamous cell carcinomas. Viral E6 and E7 oncogenes cooperate to achieve c...

    Authors: Mark A Merkley, Ellen Hildebrandt, Robert H Podolsky, Hilal Arnouk, Daron G Ferris, William S Dynan and Hubert Stöppler
    Citation: Proteome Science 2009 7:29
  25. Although much is known about signal transduction downstream of insulin-like growth factor-1 (IGF-1), relatively little is known about the global changes in protein expression induced by this hormone. In this s...

    Authors: Charles C King, Kathyrn Bouic and Theodore Friedmann
    Citation: Proteome Science 2009 7:28
  26. Predicting the function of an unknown protein is an essential goal in bioinformatics. Sequence similarity-based approaches are widely used for function prediction; however, they are often inadequate in the abs...

    Authors: Bum Ju Lee, Moon Sun Shin, Young Joon Oh, Hae Seok Oh and Keun Ho Ryu
    Citation: Proteome Science 2009 7:27
  27. Prednisone, one of the most highly prescribed drugs, has well characterized effects on gene transcription mediated by the glucocorticoid receptor. These effects are typically occurring on the scale of hours. P...

    Authors: Erica KM Reeves, Heather Gordish-Dressman, Eric P Hoffman and Yetrib Hathout
    Citation: Proteome Science 2009 7:26
  28. Abnormal activation of protease activities during experimental autoimmune encephalomyelitis (EAE) in rats, a rodent model of multiple sclerosis, have been implicated in either the direct destruction of myelin ...

    Authors: Mohit Raja Jain, Shengjie Bian, Tong Liu, Jun Hu, Stella Elkabes and Hong Li
    Citation: Proteome Science 2009 7:25
  29. The in vitro stationary phase proteome of the human pathogen Shigella dysenteriae serotype 1 (SD1) was quantitatively analyzed in Coomassie Blue G250 (CBB)-stained 2D gels. More than four hundred and fifty protei...

    Authors: Srilatha Kuntumalla, John C Braisted, Shih-Ting Huang, Prashanth P Parmar, David J Clark, Hamid Alami, Quanshun Zhang, Arthur Donohue-Rolfe, Saul Tzipori, Robert D Fleischmann, Scott N Peterson and Rembert Pieper
    Citation: Proteome Science 2009 7:22
  30. Ruk/CIN85 is a mammalian adaptor molecule with three SH3 domains. Using its SH3 domains Ruk/CIN85 can cluster multiple proteins and protein complexes, and, consequently, facilitates organisation of elaborate p...

    Authors: Serhiy Havrylov, Yuriy Rzhepetskyy, Agata Malinowska, Lyudmyla Drobot and Maria Jolanta Redowicz
    Citation: Proteome Science 2009 7:21
  31. Mitochondrial proteins are central to various metabolic activities and are key regulators of apoptosis. Disturbance of mitochondrial proteins is therefore often associated with disease. Large scale protein dat...

    Authors: Johan Palmfeldt, Søren Vang, Vibeke Stenbroen, Christina B Pedersen, Jane H Christensen, Peter Bross and Niels Gregersen
    Citation: Proteome Science 2009 7:20
  32. Mass spectrometry is increasingly being used to discover proteins or protein profiles associated with disease. Experimental design of mass-spectrometry studies has come under close scrutiny and the importance ...

    Authors: Wouter Wegdam, Perry D Moerland, Marrije R Buist, Emiel Ver Loren van Themaat, Boris Bleijlevens, Huub CJ Hoefsloot, Chris G de Koster and Johannes MFG Aerts
    Citation: Proteome Science 2009 7:19
  33. Plant growth-promoting bacteria can alleviate the inhibitory effects of various heavy metals on plant growth, via decreasing levels of stress-induced ethylene. However, little has been done to detect any mecha...

    Authors: Zhenyu Cheng, Yi-Yun C Wei, Wilson WL Sung, Bernard R Glick and Brendan J McConkey
    Citation: Proteome Science 2009 7:18
  34. Cervical-vaginal fluid (CVF) plays an important role in the prevention of gynecological infections, although little is known about the contribution of CVF proteins to the immunity of the lower female genital t...

    Authors: Geert Zegels, Geert AA Van Raemdonck, Edmond P Coen, Wiebren AA Tjalma and Xaveer WM Van Ostade
    Citation: Proteome Science 2009 7:17
  35. Many putative disease blood biomarkers discovered in genomic and proteomic studies await validation in large clinically annotated cohorts of patient samples. ELISA assays require large quantities of precious b...

    Authors: Adriana Aguilar-Mahecha, Christiane Cantin, Maureen O'Connor-McCourt, Andre Nantel and Mark Basik
    Citation: Proteome Science 2009 7:15
  36. Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is a commensal of horses and an opportunistic pathogen in many animals and humans. Some strains produce copious amounts of hyaluronic acid, making S. zo...

    Authors: Esteban Marcellin, Christian W Gruber, Colin Archer, David J Craik and Lars K Nielsen
    Citation: Proteome Science 2009 7:13
  37. Ozone is a major component of air pollution. Exposure to this powerful oxidizing agent can cause or exacerbate many lung conditions, especially those involving innate immunity. Surfactant protein-A (SP-A) play...

    Authors: Rizwanul Haque, Todd M Umstead, Willard M Freeman, Joanna Floros and David S Phelps
    Citation: Proteome Science 2009 7:12
  38. The small intestine is an important human organ that plays a central role in many physiological functions including digestion, absorption, secretion and defense. Duodenal pathologies include, for instance, the...

    Authors: Maria Paola Simula, Renato Cannizzaro, Maria Dolores Marin, Alessandro Pavan, Giuseppe Toffoli, Vincenzo Canzonieri and Valli De Re
    Citation: Proteome Science 2009 7:10
  39. Mass spectrometers can produce a large number of tandem mass spectra. They are unfortunately noise-contaminated. Noises can affect the quality of tandem mass spectra and thus increase the false positives and f...

    Authors: Jiarui Ding, Jinhong Shi, Guy G Poirier and Fang-Xiang Wu
    Citation: Proteome Science 2009 7:9
  40. Acute lymphoblastic leukemia (ALL) is a common form of cancer in children. Currently, bone marrow biopsy is used for diagnosis. Noninvasive biomarkers for the early diagnosis of pediatric ALL are urgently need...

    Authors: Linan Shi, Jun Zhang, Peng Wu, Kai Feng, Jing Li, Zhensheng Xie, Peng Xue, Tanxi Cai, Ziyou Cui, Xiulan Chen, Junjie Hou, Jianzhong Zhang and Fuquan Yang
    Citation: Proteome Science 2009 7:7
  41. Spectral counting is a shotgun proteomics approach comprising the identification and relative quantitation of thousands of proteins in complex mixtures. However, this strategy generates bewildering amounts of ...

    Authors: Paulo C Carvalho, Juliana SG Fischer, Emily I Chen, Gilberto B Domont, Maria GC Carvalho, Wim M Degrave, John R Yates III and Valmir C Barbosa
    Citation: Proteome Science 2009 7:6

    The Related Article to this article has been published in Nature Protocols 2015 11:nprot.2015.133

  42. Yersinia pestis proteins were sequentially extracted from crude membranes with a high salt buffer (2.5 M NaBr), an alkaline solution (180 mM Na2CO3, pH 11.3) and membrane denaturants (8 M urea, 2 M thiourea and ...

    Authors: Rembert Pieper, Shih-Ting Huang, David J Clark, Jeffrey M Robinson, Hamid Alami, Prashanth P Parmar, Moo-Jin Suh, Srilatha Kuntumalla, Christine L Bunai, Robert D Perry, Robert D Fleischmann and Scott N Peterson
    Citation: Proteome Science 2009 7:5
  43. Macrophages are involved in a number of key physiological processes and complex responses such as inflammatory, immunological, infectious diseases and iron homeostasis. These cells are specialised for iron sto...

    Authors: Rita Polati, Annalisa Castagna, Alessandra Bossi, Natascia Campostrini, Federica Zaninotto, Anna Maria Timperio, Lello Zolla, Oliviero Olivieri, Roberto Corrocher and Domenico Girelli
    Citation: Proteome Science 2009 7:4

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