Table 4 Differentially expressed HSPs proteins in decidua of 10 patients with EMA and 10 controls identified using PRM-based targeted proteomics
No | Protein name | Gene name | Uniprot ID | Fold change | P-Value |
|---|---|---|---|---|---|
Down-regulated HSPs in decidua tissue with EMA | |||||
1 | Heat shock protein HSP 90-alpha | HSP90AA1 | P07900 | 0.75 | 0.15 |
2 | 60kDa heat shock protein, mitochondrial | HSPD1 | P10809 | 0.61 | 0.18 |
3 | Heat shock protein HSP 90-beta | HSP90AB1 | P08238 | 0. 81 | 0.30 |
4 | 10kDa heat shock protein, mitochondrial | HPSE1 | P61604 | 0.81 | 0.37 |
5 | Heat shock 70 kDa protein 4 | HSPA4 | P34932 | 0.86 | 0.41 |
6 | Endoplasmic reticulum chaperone BiP | HSPA5 | P11021 | 0.86 | 0.44 |
7 | Heat shock 70 kDa protein 13 | HSPA13 | P48723 | 1.3 | 0.54 |
8 | Heat shock-related 70 kDa protein 2 | HSPA2 | P54652 | 0.93 | 0.69 |
9 | Stress-70 protein, mitochondrial | HSPA9 | P38646 | 0.91 | 0.70 |
10 | Calcium-regulated heat-stable protein 1 | CARHSP1 | Q9Y2V2 | 0.97 | 0.87 |
11 | Endoplasmin | HSP90B1 | P14625 | 0.99 | 0.96 |
Up-regulated in decidua tissue with EMA | |||||
12 | Basement membrane-specific heparan sulfate proteoglycan core protein | HSPG2 | P98160 | 1.42 | 0.35 |
13 | Heat shock protein beta-6 | HSPB6 | O14558 | 1.16 | 0.50 |
14 | Heat shock protein beta-1 | HSPB1 | P04792 | 1.23 | 0.53 |
15 | Heat shock protein 105 kDa | HSPH1 | Q92598 | 0.96 | 0.85 |
16 | Heat shock 70 kDa protein 1A | HSPA1A | P0DMV8 | 1.03 | 0.91 |