Table 5 Differentially expressed HSPs proteins in villi of 10 patients with EMA and 10 controls identified using PRM-based targeted proteomics

Down-regulated HSPs in villi tissue with EMA

1

Heat shock protein HSP 90-beta

HSP90AB1

P08238

0.58

0.0008

2

60kDa heat shock protein, mitochondrial

HSPD1

P10809

0.44

0.039

3

Heat shock 70 kDa protein 13

HSPA13

P48723

0.44

0.048

4

Heat shock 70 kDa protein 4

HSPA4

P34932

0.69

0.11

5

Heat shock protein HSP 90-alpha

HSP90AA1

P07900

0.76

0.14

6

Heat shock-related 70 kDa protein 2

HSPA2

P54652

0.74

0.17

7

Endoplasmic reticulum chaperone BiP

HSPA5

P11021

0.72

0.23

8

Stress-70 protein, mitochondrial

HSPA9

P38646

0.79

0.23

9

10kDa heat shock protein, mitochondrial

HPSE1

P61604

0.85

0.37

10

Heat shock protein 105 kDa

HSPH1

Q92598

0.83

0.40

11

Endoplasmin

HSP90B1

P14625

0.94

0.79

Up-regulated in villi tissue with EMA

12

Heat shock 70 kDa protein 1A

HSPA1A

P0DMV8

1.46

0.11

13

Basement membrane-specific heparan sulfate proteoglycan core protein

HSPG2

P98160

1.29

0.32

14

Heat shock protein beta-1

HSPB1

P04792

1.29

0.35

15

Calcium-regulated heat-stable protein 1

CARHSP1

Q9Y2V2

1.28

0.36

16

Heat shock protein beta-6

HSPB6

O14558

1.01

0.95