Table 2 Part of the identified proteins that may be interesting in potential biomarker discovery of early ischemia in myocardium
Protein name | Function | Distinct peptide | MW(Da) | Organ specific | Clinical marker |
|---|---|---|---|---|---|
Isoform M1 of Pyruvate kinase isozymes M1/M2 | metabolism | 12 | 58,062.4 | yes | yes |
Actin, alpha cardiac muscle 1 | cytoskeleton | 8 | 42,019.2 | yes | |
Aspartate aminotransferase 1 | metabolism (amino acid) | 6 | 46,247.7 | yes | |
Creatine kinase M-type | energ transduction | 15 | 43,101.4 | yes | yes |
Heart -fatty acid-binding protein, | lipid transport | 9 | 14,858.1 | yes | yes |
Glyceraldehyde-3-phosphate dehydrogenase | metabolism (glycolysis) | 14 | 36,053.4 | ||
L-lactate dehydrogenase B chain | metabolism (glycolysis) | 14 | 36,638.7 | yes | yes |
Myoglobin | oxygen transport | 17 | 17,183.9 | yes | yes |
Isoform 1 of Triosephosphate isomerase | metabolism (glycolysis) | 12 | 30,791.2 | ||
Isoform 8 of Titin | cytoskeletal activity | 4 | 3829,893.5 | yes | |
Glucose-6-phosphate isomerase | metabolism (glycolysis) | 5 | 63147.5 | ||
Isoform 1 of Gelsolin | cytoskeletal activity | 9 | 85697.9 | ||
Phosphoglycerate mutase 2 | metabolism (glycolysis) | 2 | 28766.3 | yes | |
Adipocyte -fatty acid-binding protein | lipid transport | 9 | 14719 | ||
Adenylate kinase 1 | ATP regeneration | 5 | 23410.9 | ||
Creatine kinase B-type | kinase activity | 2 | 42644.5 | ||
Four and a half LIM domains 1 variant | protein binding | 5 | 33578.9 | ||
Malate dehydrogenase, cytoplasmic | metabolism (glycolysis) | 12 | 36426.3 | ||
Phosphatidylethanolamine-binding protein 1 | protease inhibitor | 8 | 21056.9 | ||
PGM1 65 kDa protein | magnesium ion binding | 3 | 64560.9 | ||
Superoxide dismutase | oxidoreductase | 1 | 15935.8 |