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Research
Identifying selective kinase inhibitors remains a major challenge. The design of bivalent inhibitors provides a rational strategy for accessing potent and selective inhibitors. While bivalent kinase inhibitors...
Proteome Science 2017 15:17
Published on: 17 July 2017
Research
Daptomycin is a recently introduced, last-resort antibiotic that displays a unique mode of action against Gram-positive bacteria that is not fully understood. Several bacterial targets have been proposed but n...
Proteome Science 2017 15:16
Published on: 1 July 2017
Review
Determining small molecule—target protein interaction is essential for the chemical proteomics. One of the most important keys to explore biological system in chemical proteomics field is finding first-class m...
Proteome Science 2017 15:15
Published on: 26 June 2017
Review
In recent years, phenotypic-based screens have become increasingly popular in drug discovery. A major challenge of this approach is that it does not provide information about the mechanism of action of the hit...
Proteome Science 2017 15:13
Published on: 24 June 2017
Review
Protein-protein interactions (PPIs) trigger a wide range of biological signaling pathways that are crucial for biomedical research and drug discovery. Various techniques have been used to study specific protei...
Proteome Science 2017 15:14
Published on: 24 June 2017
Research
Liver models that closely mimic the in vivo microenvironment are useful for understanding liver functions, capabilities, and intercellular communication processes. Three-dimensional (3D) liver models assembled...
Proteome Science 2017 15:12
Published on: 20 June 2017
Research
Unlike humans, there is currently no publicly available reference mass spectrometry-based circulating acellular proteome data for sheep, limiting the analysis and interpretation of a range of physiological cha...
Proteome Science 2017 15:11
Published on: 10 June 2017
Research
In poultry production intestinal health and function is paramount to achieving efficient feed utilisation and growth. Uncovering the localised molecular mechanisms that occur during the early and important per...
Proteome Science 2017 15:10
Published on: 30 May 2017
Research
Drought (Water deficit, WD) poses a serious threat to extensively economic losses of trees throughout the world. Chinese dwarf cherry (Cerasus humilis) is a good perennial plant for studying the physiological and...
Proteome Science 2017 15:9
Published on: 8 May 2017
Research
Data from biological samples and medical evaluations plays an essential part in clinical decision making. This data is equally important in clinical studies and it is critical to have an infrastructure that en...
Proteome Science 2017 15:8
Published on: 21 April 2017
Research
Hepatitis B virus (HBV) is a global health problem, and infected patients if left untreated may develop cirrhosis and eventually hepatocellular carcinoma. This study aims to enlighten pathways associated with ...
Proteome Science 2017 15:7
Published on: 20 April 2017
Research
Reactive oxygen species (ROS) production is an early event in the immune response of plants. ROS production affects the redox-based modification of cysteine residues in redox proteins, which contribute to prot...
Proteome Science 2017 15:6
Published on: 13 April 2017
Research
Malaria continues to be a great public health concern due to the significant mortality and morbidity associated with the disease especially in developing countries. Microparticles (MPs), also called plasma mem...
Proteome Science 2017 15:5
Published on: 24 March 2017
Research
Eggshells which consist largely of calcareous outer shell and shell membranes, constitute a significant part of poultry hatchery waste. The shell membranes (ESM) not only contain proteins that originate from e...
Proteome Science 2017 15:4
Published on: 3 March 2017
Research
Non-starch polysaccharide enzymes (NSPEs) have long been used in monogastric animal feed production to degrade non-starch polysaccharides (NSPs) to oligosaccharides in order to promote growth performance and g...
Proteome Science 2017 15:3
Published on: 10 January 2017
Research
Milk is the most important food for growth and development of the neonate, because of its nutrient composition and presence of many bioactive proteins. Differences between human and bovine milk in low abundant...
Proteome Science 2017 15:1
Published on: 5 January 2017
Research
The degradation of the steppe of Inner Mongolia, due to overgrazing, has resulted in ecosystem damage as well as extensive reductions in sheep production. The growth performance of sheep is greatly reduced bec...
Proteome Science 2017 15:2
Published on: 5 January 2017
Methodology
Proteomic matrix-assisted laser desorption/ionisation (MALDI) linear time-of-flight (TOF) mass spectrometry (MS) may be used to produce protein profiles from biological samples with the aim of discovering biom...
Proteome Science 2016 14:19
Published on: 7 December 2016
Research
Myoglobin (Mb) is a sarcoplasmic heme protein primarily responsible for meat color and its chemistry is species specific. 4-hydroxy-2-nonenal (HNE) is a cytotoxic lipid derived aldehyde detected in meat and wa...
Proteome Science 2016 14:18
Published on: 16 November 2016
Research
Human follicular fluid (FF) is a unique biological fluid in which the oocyte develops in vivo, and presents an optimal source for non-invasive biochemical predictors. Oocyte quality directly influences the emb...
Proteome Science 2016 14:17
Published on: 14 November 2016
Research
Daurian ground squirrels (Spermophilus dauricus) deviate from significant increase of protein catabolism and loss of myofibrillar contents during long period of hibernation inactivity.
Proteome Science 2016 14:16
Published on: 8 November 2016
Research
The acquisition of iron is important for the pathogenicity of bacteria and blood. Three different culture environments (Fe stimulation, blood agar plate and normal plate) were used to stimulate Enterobacter cloac...
Proteome Science 2016 14:15
Published on: 18 October 2016
Research
Low temperature is one of the crucial environmental factors limiting the productivity and distribution of plants. Sea buckthorn (Hippophae rhamnoides L.), a well recognized multipurpose plant species, live succes...
Proteome Science 2016 14:14
Published on: 7 October 2016
Research
Plenty of proteomic studies were performed to characterize the allotetraploid upland cotton fiber elongation process, whereas little is known about the elongating diploid cotton fiber proteome.
Proteome Science 2016 14:13
Published on: 8 September 2016
Research
Epidermal growth factor receptor (EGFR) mutation-induced drug resistance is a difficult problem in lung cancer treatment. Studying the molecular mechanisms of drug resistance can help to develop corresponding ...
Proteome Science 2016 14:12
Published on: 8 September 2016
Proteome Science is affiliated with the Korean Human Proteome Organization (KHUPO). KHUPO is a global leader in both domestic and global proteomics research, establishing an industry-academia-government joint cooperation system to effectively carry out global proteome projects and research such as the human genome project
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