A dynamic plasma membrane proteome analysis of alcohol-induced liver cirrhosis

Table 1 Differentially expressed proteins identified in this work

*Spot*	*Accession NO.*	*Protein description*	*Sco.*	pI	*MW (KDa)*	*Cov.*	*Exp.6*	*Exp.9*	*Function*	Cellular location*
6-1U,9-1U	ANXA5_RAT	Annexin A5	191	4.93	35.8	23%	2.36	2.4	binding	cytoplasm
6-2U,9-2U	THTM_RAT	3-mercaptopyruvate sulfurtransferase	194	5.88	33.2	29%	4.42	2.3	enzyme	Cytoplasm
6-3U,9-3U	CATL1_RAT	Cathepsin L1 precursor	83	6.37	38.2	26%	5.45	+∞	enzyme,binding	PM
6-4U,9-4U	ETFB_RAT	Electron transfer flavoprotein subunit beta	293	7.6	27.9	48%	3.77	+∞	enzyme	Mito.
6-5U,9-5U	MYH9_RAT	Myosin-9	168	5.49	227.6	2%	2.01	2.27	enzyme,binding	Cytoplasm
6-6U,9-6U	ARGI1_RAT	Arginase-1	101	6.76	35.1	15%	+∞	2.03	binding	PM
6-7U,9-7U	MYH9_RAT	Myosin-9	168	5.49	227.6	2%	2.00	5.69	binding,enzyme	Cytoplasm
6-8U,9-8U	ANXA2_RAT	Annexin A2	313	7.55	38.9	27%	3.69	2.92	binding	PM
6-9D,9-9D	PRDX1_RAT	Peroxiredoxin-1	49	8.27	22.3	9%	0.36	0.52	binding, peroxiredoxin, protein homodimerization	Cytoplasm, Melanosome
6-10D,9-10D	GBB2_RAT	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	39	5.6	38	3%	0.62	0.64	signal transduction, calcium channel regulator	PM
6-11D,9-11D	ANXA6_RAT	Annexin A6	466	5.39	76.1	45%	0.44	0.18	binding	PM, melanosome
6-12D,9-12D	ANXA6_RAT	Annexin A6	466	5.39	76.1	45%	0.50	0.17	binding	PM, melanosome
6-13D,9-13D	K2C8_RAT	Keratin, type II cytoskeletal 8	320	5.83	54	35%	0.16	0.56	binding, structural	PM
6-14D,9-14D	K1C18_RAT	Keratin, type I cytoskeletal 18	724	5.17	47.7	47%	0.31	0.65	structural	PM
6-15D,9-15D	ANXA3_RAT	Annexin A3	86	5.96	36.6	20%	0.64	0.27	binding,phospholipase A2 inhibitor	PM
6-16D,9-16D	PDIA3_RAT	Protein disulfide-isomerase A3 precursor	88	5.88	57	15%	0.65	-∞	enzyme	ER

Sco score, MW molecular weight, Cov. Sequence coverage, Exp. Expression (ratio of experimental group to control group), PM plasma membrane including external side of plasma membrane, plasma membrane, intermediate filament, Mito. Mitochondrion, ER. endoplasmic reticulum.

ISSN: 1477-5956