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Table 5 Proteins down-regulated by glucose

From: Comparative proteomic analysis of transition of saccharomyces cerevisiae from glucose-deficient medium to glucose-rich medium

A

Name

115:113

P

115:114

P

116:113

P

116:114

P

Ave

SD

t-test

Hxk1p, Hexokinase A

0.3908

0.0002

0.4529

0.0025

0.5200

0.0015

0.5970

0.0181

0.4902

0.0768

0.0014

Pgi1p, Phosphoglucose Isomerase

0.6792

0.0267

0.4529

0.0042

0.7178

0.2011

0.4613

0.0416

0.5778

0.1215

0.0092

Pgm2p, Phosphoglucomutase

0.4875

0.0137

0.4246

0.0068

0.6918

0.0936

0.6026

0.0476

0.5516

0.1031

0.0048

Fbp1p, Fructose-1,6-Bisphosphatase

0.1528

0.0001

0.1259

0.0001

0.0731

0.0001

0.0625

0.0001

0.1036

0.0372

0.0001

Icl1p, Isocitrate Lyase

0.3281

0.0001

0.2630

0.0001

0.2630

0.0001

0.2128

0.0001

0.2667

0.0409

0.0001

Mls1p, Malate Synthase

0.5395

0.0062

0.4285

0.0019

0.7656

0.05704

0.5916

0.0175

0.5813

0.1216

0.0094

Ach1p, Acetyl CoA Hydrolase

0.4831

0.0021

0.5152

0.0036

0.6546

0.0213

0.6855

0.0513

0.5846

0.0869

0.0037

Atp2p, Mitochondrial ATP Synthase Subunit Beta

0.4966

0.0059

0.2938

0.0053

0.6252

0.0219

0.3597

0.0200

0.4438

0.1277

0.0048

Om45p, Mitochondrial Outer Membrane Protein

0.4613

0.0045

0.5702

0.0144

0.4656

0.0020

0.5649

0.0064

0.5155

0.0521

0.0005

Hsp12p, Heat Shock Protein

0.3565

0.0091

0.3251

0.0945

0.2630

0.0020

0.2466

0.0126

0.2978

0.0448

0.0001

Hsp26p, Heat Shock Protein

0.5445

0.0130

0.5861

0.0162

0.3698

0.0013

0.4018

0.0016

0.4756

0.0916

0.0022

Hsp30p, Heat Shock Protein

0.3981

0.0922

0.3221

0.0446

0.2312

0.0393

0.1905

0.0175

0.2479

0.0550

0.0006

B

Accession #

Name

Peptides (95%)

113:114

P

115:116

P

t-test

gi|6321184

Hxk1p, Hexokinase A

20

1.3804

0.7068

0.9462

0.9299

0.5894

gi|6319673

Pgi1p, Phosphoglucose Isomerase

26

0.6368

0.3942

0.9204

0.2883

0.3626

gi|817863

Pgm2p, Phosphoglucomutase

18

0.8241

0.7017

0.6730

0.2974

0.1858

gi|6323409

Fbp1p, Fructose-1,6-Bisphosphatase

7

0.8166

0.1819

1.9953

0.1888

0.6160

gi|6320908

Icl1p, Isocitrate Lyase

14

0.7870

0.2416

1.2589

0.1990

0.9383

gi|6324212

Mls1p, Malate Synthase

13

0.7586

0.5169

0.7112

0.2358

0.0568

gi|6319456

Ach1p, Acetyl CoA Hydrolase

16

1.0375

0.6989

0.7311

0.1846

0.5882

gi|84028178

Atp2p, Mitochondrial ATP Synthase Subunit Beta

20

0.6081

0.9613

0.8472

0.4900

0.2633

gi|730224

Om45p, Mitochondrial Outer Membrane Protein

17

1.2023

0.5644

0.9908

0.6866

0.5289

gi|836740

Hsp12p, Heat Shock Protein

35

0.9462

0.2305

1.3428

0.4280

0.5991

gi|6319546

Hsp26p, Heat Shock Protein

41

1.0965

0.8963

1.4859

0.1689

0.3752

gi|6319869

Hsp30p, Heat Shock Protein

6

0.7943

0.4318

1.7701

0.5325

0.6662

  1. (A) Proteins that decreased their relative levels in response to glucose re-feeding. Average ratios (Avg) and standard deviations (SD) are given, along with the p-values (P) calculated for each protein's ratio by ProteinPilotTM 4.0 based on the ratios of each identified peptide. A one-sample Student's t-test was used to confirm that each protein's set of ratios for all four comparisons was significantly different from 1 and all p-values are <0.01.
  2. (B) Ratios of 113:114; starved:starved and 115:116; re-fed:re-fed with the number of distinct peptides having at least 95% confidence and a p-value (P) greater than 0.05 calculated for each protein's ratio by ProteinPilotTM 4.0 based on the ratios of each identified peptide. A one-sample Student's t-test was used to confirm that each protein's set of ratios for both comparisons was not significantly different from 1 and all p-values are >0.05.
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Proteome Science

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