Table 2 Rosuvastatin-modulated proteins identified by LC-MS/MS
Spot number | Protein name a) | Accession number b) | Theoretical MW (kDa)/pI c) | Experimental MW (kDa)/pI d) | Sequence coverage (%) | MOWSE score | Peptides matched |
|---|---|---|---|---|---|---|---|
U1 | Mitochondrial ATP synthase beta subunit precursor | 32189394 | 51.8/5.0 | 48.6/5.0 | 63 | 1177 | 22 |
U2 | ER-60 protease | 1208427 | 57.2/5.9 | 56.5/5.9 | 54 | 687 | 28 |
U3 | Ubiquinol-cytochrome c reductase core I protein | 515634 | 53.2/5.9 | 46.7/5.7 | 58 | 507 | 23 |
U4 | Cargo selection protein TIP47 | 3095186 | 47.2/5.3 | 45.1/5.3 | 41 | 473 | 15 |
U5 | Transaldolase | 5803187 | 37.7/6.4 | 36.5/6.1 | 44 | 216 | 16 |
U6 | L-lactate dehydrogenase B | 4557032 | 36.9/5.7 | 35.7/5.9 | 40 | 505 | 15 |
U7 | Eukaryotic translation initiation factor 3, subunit 2 beta | 4503513 | 36.9/5.4 | 36.6/5.6 | 38 | 273 | 11 |
U8 | Glyceraldehyde-3-phosphate dehydrogenase | 31645 | 36.2/8.26 | 36.2/5.5 | 22 | 297 | 6 |
U9 | Annexin V, chain A | 157833780 | 36.0/4.9 | 35.1/5.1 | 27 | 125 | 11 |
U10 | Glia maturation factor, beta | 4758442 | 16.7/5.2 | 26.5/5.4 | 45 | 208 | 8 |
U11 | SH3 domain binding glutamic acid-rich protein-like | 4506925 | 12.8/5.2 | 16.2/5.5 | 20 | 91 | 2 |
U12 | Enhancer of rudimentary homolog | 4758302 | 12.3/5.6 | 12.8/5.6 | 17 | 61 | 12 |
U13 | Phosphohistidine phosphatase 1 isoform 3 | 24475861 | 13.8/5.7 | 14.4/5.8 | 26 | 137 | 5 |
U14 | Cytochrome c oxidase subunit V precursor | 190885499 | 16.8/6.3 | 14.2/5.3 | 22 | 99 | 4 |
U15 | Galectin-1 | 4504981 | 14.7/5.7 | 14.5/5.0 | 38 | 190 | 5 |
U16 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d, isoform a | 5453559 | 18.5/5.2 | 22.6/5.4 | 31 | 127 | 5 |
U17 | Rho GDP dissociation inhibitor (GDI) beta | 56676393 | 23.0/5.1 | 26.7/5.2 | 27 | 140 | 7 |