Table 2 Abundance modified proteins in GCMN

Post-translational modification, protein turnover, chaperones (15)

CTSD cathepsin D -

breast [52] ovarian [53] melanoma [14,15]

IPI00011229

0.024

6.8

1509

HSP90AA1 heat shock protein 90-kDa alpha (cytosolic), class A member 1 isoform 1

IPI00382470

0.02

3.4

3320

HSP90AB1 heat shock protein HSP 90-beta

IPI00414676

0.013

3.6

3326

HSPA1A;HSPA1B heat shock 70-kDa protein 1

IPI00304925

0.031

2.4

3303

HSPA8 Isoform 1 of heat shock cognate 71-kDa protein

IPI00003865

0.0016

5.2

3312

HSPB1 heat shock protein beta-1

IPI00025512

0.0027

3.8

3315

PDIA3 protein disulfide-isomerase A3

ovarian [54]

IPI00025252

0.012

5.4

2923

PHB prohibitin

gastric carcinoma [28], thyroid cancer [29], hepatocellular carcinoma [30], melanoma [16,17]

IPI00017334

0.025

5.3

5245

PSMB1 proteasome subunit beta type-1

IPI00025019

0.045

3.5

5689

SFN Isoform 1 of 14-3-3 protein sigma

IPI00013890

0.027

1.7

2810

YWHAB long isoform of 14-3-3beta/alpha

IPI00216318

0.0012

2.2

7529

YWHAE 14-3-3epsilon

IPI00000816

0.0051

4.2

7531

YWHAG 14-3-3gamma

IPI00220642

0.024

2.1

7532

YWHAQ 14-3-3theta

IPI00018146

0.00088

3.3

10971

YWHAZ 14-3-3zeta/delta

IPI00021263

0.0021

2.6

7534

Cytoskeleton (4)

CAPZA1 F-actin-capping protein subunit alpha-1

IPI00005969

0.0044

2.6

829

CAPZB cDNA, FLJ93598, highly similar to Homo sapiens capping protein (actin filament) muscle Z-line, beta

IPI00641107

0.017

2.9

832

Isoform 2 of dynein heavy chain 2, axonemal

IPI00651691

0.004

2.3

146754

Isoform 2 of myosin light chain kinase, smooth muscle

IPI00221255

0.0018

2.6

4638

General function prediction only (5)

CDC42 Isoform 2 of cell-division control protein 42 homolog

immune escape of cancer [55]

IPI00016786

0.017

2.8

998

CSPG4 chondroitin sulfate proteoglycan 4

melanoma, human carcinoma, sarcoma [18]

IPI00019157

0.026

2.3

1464

HNRNPA2B1 isoform B1 of heterogeneous nuclear ribonucleoproteins A2/B1

glioblastoma[56] lung cancer [57]

IPI00396378

0.015

4.9

3181

PEBP1 phosphatidylethanolamine-binding protein 1

prostate [58], breast [59], gastrointestinal stromal [60], melanoma [19], ovarian [61]

IPI00219446

0.026

2.9

5037

RAC1 isoform A of Ras-related C3 botulinum toxin substrate 1

skin tumor [62]

IPI00010271

0.0092

3.7

5879

Carbohydrate transport and metabolism (3)

ALDOA fructose-bisphosphate aldolase A

IPI00465439

0.034

4

226

Uncharacterized protein ENSP00000348237

IPI00453476

0.0012

3.1

FLG2 filaggrin-2

IPI00397801

0.000021

0.2

388698

Energy production and conversion (2)

ATP5B ATP synthase subunit beta, mitochondrial

IPI00303476

0.032

5

506

ETFA electron transfer flavoprotein subunit alpha, mitochondrial

IPI00010810

0.0028

3.4

2108

Signal transduction mechanisms (3)

ARHGDIA rho GDP-dissociation inhibitor 1

mesothelioma [63]

IPI00003815

0.047

3.4

396

FBLN5 fibulin-5

breast cancer [64]

IPI00294615

0.0028

3.4

10516

RYR3 uncharacterized protein RYR3

IPI00217185

0.013

2.7

6263

Intracellular trafficking, secretion, and vesicular transport (3)

ANXA1 annexin A1

breast cancer [65]

IPI00218918

0.03

3

301

ANXA2 annexin A2 isoform 1

breast cancer [66]

IPI00418169

0.0059

1.8

302

ANXA5 annexin A5

colorectal cancer [67]

IPI00329801

0.025

3.8

308

Amino acid transport and metabolism (2)

PHGDH D-3-phosphoglycerate dehydrogenase

breast cancer [68]

IPI00011200

0.031

5

26227

TPSB2 TPSB2

IPI00419942

0.043

2.2

64499

Lipid transport and metabolism (2)

ECH1 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrial

IPI00011416

0.00034

3.1

1891

FASN fatty acid synthase

breast cancer, endometrial cancer [69] prostate cancer [70]

IPI00026781

0.023

3.1

2194

Translation, ribosomal structure, and biogenesis (2)

EEF1A1 elongation factor 1-alpha 1

IPI00396485

0.012

2.5

1915

RPSA ribosomal protein SA, 33-kDa protein

melanoma [20]

IPI00413108

0.024

2.9

3921

RNA processing and modification (1)

HNRNPU short isoform of heterogeneous nuclear ribonucleoprotein U

IPI00479217

0.0037

2.3

3192

Cell cycle control, cell division, chromosome partitioning (1)

KRT1 keratin, type II cytoskeletal 1

IPI00220327

0.016

0.7

3848

Inorganic ion transport and metabolism (1)

CLIC1 chloride intracellular channel protein 1

IPI00010896

0.015

3.5

1192

Secondary metabolites biosynthesis, transport, and catabolism (1)

ADH1B alcohol dehydrogenase 1B

IPI00473031

0.025

0.2

125

Function unknown (1)

HRNR hornerin

IPI00398625

0.035

0.2

388697