Figure 2

Flow chart of the main tasks involved in this study: The main workflow of this study starts with generation of the solvent excluded surface using the 3-D atomic coordinates and the generation of a 2-D mapping using dimension reduction. The reduced representation is enriched with geometric and biochemical features calculated from the 3-D surface points, such as electrostatic potential, hydrophobicity, and curvature. The enriched 2-D surface representation of proteins can then be compared using image registration methods. The 2D-3D mapping of the protein surface can also be utilized to texture-map arbitrary images back onto the 3-D surface, to aid in visualization.