Accuracy improvement in protein complex prediction from protein interaction networks by refining cluster overlaps

Table 4 Clustering results of four density-based approaches and their accuracy on BioGRID data

method	number of clusters	average overlap rate	average f-score
MCODE	301	0.000	0.229
DPClus	696	0.167	0.331
Entropy	47	0.000	0.169
Modified-Entropy	243	0.094	0.175

We tested four density-based graph-clustering approaches on the yeast protein-protein interaction data from BioGRID. Their clustering results and the average overlap rates are shown. As accuracy of each method on predicting protein complexes, we measured the average f-score of the clusters comparing to protein complexes experimentally determined.

ISSN: 1477-5956