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Table 1 Proteins with differential levels in postsurgical sera compared with those in presurgical sera of AAA patients

From: Proteomic profiling for the identification of serum diagnostic biomarkers for abdominal and thoracic aortic aneurysms

Unused protScore a

% Coverage b

Peptides c(95%)

Uniplot number

Gene symbol

Protein name

iTRAQ ratio daverage ± SE

p value e

Molecular function

 

(postsurgical vs. presurgical)

(patient vs. control)

 

Increased proteins

37.7

86.9

28

P02735

SAA1

Serum amyloid A protein

8.09 ± 3.60

-f

Acute phase reactant

48.8

56.5

37

P01011

SERPINA3

Alpha-1-antichymotrypsin

1.88 ± 0.12

0.0006

Protease inhibitor

53.1

67.7

56

P02763

ORM1

Alpha-1-acid glycoprotein 1

1.85 ± 0.21

0.0250

Transporter

26.2

54.5

14

P02750

LRG1

Leucine-rich alpha-2-glycoprotein

1.85 ± 0.15

0.0032

Unknown

26.5

40.1

13

P02748

C9

Complement component C9

1.36 ± 0.09

0.0135

Complement

116.9

80.9

139

P01009

SERPINA1

Alpha-1-antitrypsin

1.32 ± 0.06

0.0081

Protease inhibitor

Decreased proteins

26.1

30.4

12

P06396

GSN

Gelsolin

0.55 ± 0.03

0.0000

Actin scavenger

37.3

54.2

29

P02765

AHSG

Alpha-2-HS-glycoprotein

0.61 ± 0.05

0.0002

Extracellular matrix

18.5

74.0

17

P02652

APOA2

Apolipoprotein A-II

0.64 ± 0.05

0.0214

Transporter

14.1

60.7

9

P02753

RBP4

Retinol-binding protein 4

0.65 ± 0.05

0.0005

Transfer/carrier protein

20.9

36.3

10

P29622

SERPINA4

Kallistatin

0.68 ± 0.06

0.0196

Protease inhibitor

10.0

25.1

6

P27169

PON1

Serum paraoxonase/arylesterase 1

0.69 ± 0.06

0.0010

Hydrolase

89.6

89.9

110

P02647

APOA1

Apolipoprotein A-I

0.70 ± 0.04

0.0238

Transporter

149.6

49.4

90

P02751

FN1

Fibronectin

0.72 ± 0.06

0.0330

Extracellular matrix

163.9

82.5

176

P02787

TF

Serotransferrin

0.73 ± 0.04

0.0004

Transfer/carrier protein

36.9

50.3

20

P04196

HRG

Histidine-rich glycoprotein

0.73 ± 0.03

0.0005

Adapter protein

234.7

81.7

207

P01023

A2M

Alpha-2-macroglobulin

0.75 ± 0.04

0.0036

Signaling molecule

44.3

35.7

26

P19823

ITIH2

Inter-alpha-trypsin inhibitor heavy chain H2

0.77 ± 0.06

0.0024

Protease inhibitor

  1. aA score of protein confidence(ProtScore) for a detected protein that is calculated from the peptide confidence from spectra that are not already “used” by higher scoring proteins in the experiments.
  2. bThe percentage of matching amino acids from identified peptides.
  3. cThe number of distinct peptides with at least 95% confidence in the experiments.
  4. diTRAQ ratio of postsurgical sera compared with those in presurgical sera (postsurgical vs. presurgical).
  5. eStatistical analysis of iTRAQ ratio of postsurgery/presurgery of patients’ sera compared with that of T2/T1 of control volunteers’ sera (patient vs. control).
  6. fProtein that did not appear in control sera.
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