Proteomic analyses of age related changes in A.BY/SnJ mouse hearts

Table 2 Aging related alterations in rodents

Pathway/Protein	Gene	This study		Literature findings
		1 → 4 m*	method	4 → 24 m ^#rodent method			Ref. ^§
*Electron transport chain*
ATP synthase subunit d.	Atp5h	down	LC-MS
ATP synthase subunit O	Atp5o	down	LC-MS
ATP synthase subunit delta.	Atp5d	down	LC-MS
ATP synthase subunit alpha	Atp5a1	down	LC-MS	down	mouse	2DE	[15]
ATP synthase subunit beta	Atp5b	down	2D DIGE	down	mouse	2DE	[15]
cytochrome c	Cycs	down	LC-MS	down	mouse	mRNA	[33]
*metabolism*
mito. pyruvate dehydrogenase E1 component subunit beta	Pdhb	down	LC-MS	down	rat	itraq	[16]
phosphoglycerate kinase 1	Pgk1	down	LC-MS	down	rat	itraq	[16]
*stress-related proteins*
heat shock protein 70	Hspa9	up	2D DIGE	down	mouse	mRNA	[33]
60 kDa heat shock protein	Hspd1	down	LC-MS
*others*
desmin	Desm	down	LC-MS	down	mouse	2DE	[15]
troponin T2	Tnnt2	down	LC-MS	down	rat	itraq	[16]
tropomyosin alpha 1	Tpm1	down	2D DIGE	down	rat, mouse	itraq, mRNA	[16, 33]
voltage dependent anion channel-1	Vdac1	down	LC-MS	down	rat	itraq	[16]
elongation factor2	Eef2	up	2D DIGE	up	mouse	2DE	[14]

* Differences between hearts of 1 month and 4 months old animals obtained within this study in A.BY/SnJ mice. Column content in bold letters.
^# Differences between hearts of ≥ 4 months and ≥ 20 months old mice published by other authors.
^§ Ref. reference.

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