Table 1 Differential expressed proteins identified by MALDI-TOF-MS between serum of HBV hepatic fibrosis and HBV carriers
Spot | Accession number | Protein name | Mass weight | pI | Sequence coverage (%) | Scores | Ratio * | Function |
|---|---|---|---|---|---|---|---|---|
1 | P02771 | Alpha-fetoprotein | 69500 | 5.31 | 19 | 203 | ↑2.01 | biomarker |
2 | P08833 | Insulin-like growth factor-binding protein 1 | 33200 | 4.9 | 23 | 262 | ↑2.01 | Cell growth |
3 | P02741 | C-reactive protein | 23760 | 5.12 | 23 | 570 | ↑2.02 | calcium binding |
4 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 105356 | 6.09 | 18 | 186 | ↑2.02 | DNA binding |
5 | P2671 | Fibrinogen alpha chain | 66818 | 7.65 | 8 | 298 | ↑2.03 | receptor binding |
6 | Q03135 | Caveolin-1 | 20472 | 6.95 | 9 | 78 | ↑2.03 | enzyme activity |
7 | P05121 | Plasminogen activator inhibitor 1 | 48577 | 6.77 | 12 | 138 | ↑2.11 | blood coagulation |
8 | P00505 | Aspartate aminotransferase | 47476 | 4.87 | 19 | 110 | ↑2.26 | catalytic activity |
9 | P01137 | Transforming growth factor beta-1 | 40412 | 5.86 | 12 | 188 | ↑2.29 | Cell growth |
10 | P04271 | Protein S100-B | 10713 | 4.43 | 8 | 154 | ↑2.31 | calcium binding |
11 | P24298 | Alanine aminotransferase 1 | 54637 | 5.11 | 13 | 908 | ↑2.89 | catalytic activity |
12 | Q14116 | Interleukin-18 | 21326 | 5.23 | 27 | 392 | ↑2.97 | signal transducer |
13 | P01375 | Tumor necrosis factor | 25644 | 5.43 | 18 | 152 | ↑3.01 | apoptotic process |
14 | P08253 | Matrix metallopeptidase 2 | 73882 | 6.57 | 30 | 150 | ↑3.01 | metastasis |
15 | P01579 | Interferon gamma | 19348 | 5.67 | 16 | 335 | ↑3.21 | receptor binding |
16 | P01034 | Cystatin-C | 13120 | 7.11 | 13 | 262 | ↑3.57 | enzyme activity |
17 | P05187 | Alkaline phosphatase | 57954 | 6.14 | 16 | 362 | ↑3.66 | hydrolase activity, |
18 | P01033 | Metalloproteinase inhibitor 1 | 23171 | 5.28 | 4 | 74 | ↑4.21 | metastasis |
19 | P07996 | Thrombospondin-1 | 25695 | 6.67 | 6 | 166 | ↑7.56 | blood coagulation |
20 | P17936 | Insulin-like growth factor-binding protein 3 | 31674 | 5.03 | 8 | 304 | ↓2.17 | Cell growth |
21 | P37231 | Peroxisome proliferator-activated receptor gamma | 57620 | 5.23 | 25 | 946 | ↓2.72 | DNA binding |
22 | P04180 | Phosphatidylcholine-sterol acyltransferase | 49578 | 5.68 | 17 | 541 | ↓2.88 | catalytic activity |
23 | P06276 | Cholinesterase | 68418 | 6.92 | 16 | 765 | ↓3.12 | catalytic activity |
24 | P02652 | Apolipoprotein A-II | 12520 | 4.74 | 28 | 552 | ↓3.22 | receptor binding |
25 | O46409 | Apolipoprotein A-IV | 43294 | 5.74 | 26 | 550 | ↓3.57 | receptor binding |
26 | Q6Q788 | Apolipoprotein A-V | 41213 | 4.97 | 13 | 394 | ↓3.59 | receptor binding |
27 | P19875 | Enolase-1 | 47481 | 7.01 | 12 | 252 | ↓5.09 | DNA binding |