Figure 6
From: Exploring the “dark matter” of a mammalian proteome by protein structure and function modeling
Putative protein-protein interactions involving sproteins. (A) A heat map showing the probability of interaction p according to the color scale on the left. (B) Representative examples of “promiscuous” sproteins, labeled according to Table 4. (C, D) Examples of sproteins (solid orange) superposed onto the parental dimeric templates (transparent): (C) ligand – D630037N19, receptor – ENSMUSP00000039175, template – estrogen receptor α (PDB-ID: 2qgw); and (D) ligand – I830091D09, receptor – ENSMUSP00000122045, template – VpreB protein (PDB-ID: 2h3n). Template receptors and ligands are colored in tan and yellow, respectively. Hot spot residues identified by PINUP are shown as red sticks.