Exploring the “dark matter” of a mammalian proteome by protein structure and function modeling

Table 2 Hydrogen bond pattern in sprotein models

Hydrogen bond type ^a	Modeled sprotein structures			Best CATH matches
Hydrogen bond type ^a	High-quality	Moderate-quality	Low-quality	High-quality	Moderate-quality
Main-main chain	0.55 ±0.13	0.45 ±0.19	0.42 ±0.19	0.61 ±0.09	0.61 ±0.14
Side-side chain	0.02 ±0.02	0.02 ±0.02	0.02 ±0.02	0.09 ±0.04	0.09 ±0.04
Main-side chain	0.10 ±0.04	0.10 ±0.04	0.10 ±0.05	0.18 ±0.07	0.17 ±0.06

^a According to HBPLUS classification.
Number of hydrogen bonds per residue is calculated by HBPLUS for modeled sprotein structures. Sprotein models are compared to a set of the best structural matches identified in the CATH library by Fr-TM-align.

ISSN: 1477-5956