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Table 4 Examples of protein-protein interactions involving sproteins

From: Exploring the “dark matter” of a mammalian proteome by protein structure and function modeling

Rank

Sprotein

Model confidence a

PPI b

CATH assignment

Domain

TM-score c

Classification

1

B930036P11

0.48

1,757

1ji4A00

0.82

1.20.1260 (Ferritin)

2

E430007D20

0.47

1,638

2x75A02

0.59

1.20.200 (Fumarase C)

3

G530013D06

0.55

1,596

3m5jB00

0.80

3.90.20 (Hemagglutinin ectodomain)

4

A730094F08

0.44

1,525

1pd3A00

0.75

1.10.287 (Helix hairpins)

5

1110020 M21

0.46

1,420

1wp1B01

0.57

1.20.1600 (Outer membrane efflux proteins)

6

2310075O16

0.45

1,416

3ud0A00

0.56

1.10.3080 (Clc chloride channel)

7

6720468P07

0.41

1,390

1wdzA00

0.62

1.20.1270 (Substrate binding domain of Dnak)

8

I830091D09

0.83

1,311

1icwB00

0.80

2.40.50 (Dihydrolipoamide Acetyltransferase)

9

G630033A22

0.52

1,295

1y9qA01

0.71

1.10.260 (434 Repressor, N-term)

10

K430331D04

0.41

1,287

2jexA01

0.97

1.10.287 (Helix hairpins)

  1. a TM-score for the top structural model estimated by e Thread; b number of putative protein-protein interactions with the remaining gene products in the mouse proteome; c TM-score between the structural model and the top CATH domain hit.
  2. Ten most “promiscuous” sproteins and their CATH assignment.