Skip to main content

Table 2 Performance comparison of TIC, MedScale, and Quantile normalization

From: Gaussian process regression model for normalization of LC-MS data using scan-level information

Batch Raw TIC MedScale Quantile
1 Positive 5.0 6.1 5.5 4.0
2 Positive 7.0 4.1 3.5 3.0
1 Negative 5.0 3.1 4.1 2.9
2 Negative 20 11 9.9 7.3
(A) Percentage of the number of ions with significant QC variation (q ΞΆ < 0.1)
Mode Raw TIC MedScale Quantile
Positive 23 40 32 62
Negative 11 19 15 105
(B) Number of statistically significant ions between cases and controls, overlapping in batch B1 and B2