Table 2 Performance comparison of TIC, MedScale, and Quantile normalization
From: Gaussian process regression model for normalization of LC-MS data using scan-level information
Batch | Raw | TIC | MedScale | Quantile |
|---|---|---|---|---|
1 Positive | 5.0 | 6.1 | 5.5 | 4.0 |
2 Positive | 7.0 | 4.1 | 3.5 | 3.0 |
1 Negative | 5.0 | 3.1 | 4.1 | 2.9 |
2 Negative | 20 | 11 | 9.9 | 7.3 |
(A) Percentage of the number of ions with significant QC variation (q ζ < 0.1) | ||||
Mode | Raw | TIC | MedScale | Quantile |
Positive | 23 | 40 | 32 | 62 |
Negative | 11 | 19 | 15 | 105 |
(B) Number of statistically significant ions between cases and controls, overlapping in batch B1 and B2 | ||||