Table 2 Families of some known cytokines
Family | Members | Action |
|---|---|---|
TNF | 20 | Pro-inflammatory |
IL-1 | 11 Members including IL-1α, IL-1β, IL-18 and IL-33 | Pro-inflammatory |
IL-6 | IL6, Leukaemia inhibitory factor, IL-11, oncostatin, ciliary neuroptic factor and cardiotropin-1 | Acute phase response, Pro-inflammatory, diverse biological activities |
IL-10 | IL-10, IL-22 | Anti-inflammatory |
Colony stimulating factors (CSF) | IL-3, granulocyte-CSF, granulocyte-macrophage CSF, macrophage CSF | Overlapping functions, distinct gene products, and have specific receptors. |
Chemokine | CXCL8 (formally known as IL-8) | Chemotactic |
Interferons | IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 | Antiviral, modulate several immune responses, share a common receptor chain, exclusively produced by activated T Cells. |