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Table 2 List of 68 host defence associated proteins identified in cows’ milk by either 2DE-MALDI-TOF or GeLC

From: Host defence related responses in bovine milk during an experimentally induced Streptococcus uberis infection

Spot #a

Protein name

Accession number

Conditionb

Defence-related functionc

14

Alpha-2-HS-glycoprotein (Fetuin)

P12763

C/M

Mod. Infl. response

18†

Angiogenin-1

NP_001071612

C/M

Antimicrobial.

23

Apolipoprotein A-I

NP_776667

C/M

Mod. Infl. response

24

Apolipoprotein A-II

P81644

M

Mod. Infl. response

25

Apolipoprotein E

Q03247

C/M

Mod. Infl. response

28 †

Azurocidin-1

DAA27509.1

C/M

Antimicrobial.

29

Beta-1,4-galactosyltransferase-1

P08037

C/M

Mod. Infl. response

30

Beta-2-microglobulin

NP_776318

C/M

Ant. Recog.

36

Cathelicidin* (2,6,7)

NP_777257

M

Antimicrobial.

37

Cathelicidin* (3,4,5,6,7)

NP_776935

M

Antimicrobial.

38

Cathelicidin-1

DAA16881

C/M

Antimicrobial.

39

Cathelicidin-2

AAA30404

M

Antimicrobial.

40

Cathelicidin-4

P33046

M

Antimicrobial.

41

Cathelicidin-7

NP_777256

M

Antimicrobial.

45

Chitinase-3-like protein-1

AAB64304

C/M

Mod. Infl. response

50 †

Common salivary protein/BSP30 b

P79125

C/M

Antimicrobial

51

Complement 4 Binding Protein alpha

ABQ12991

C/M

Mod. Infl. response

52†

Complement 8, gamma polypeptide

NP_001103546

C

Antimicrobial.

53

Complement component C3

DAA27847

C/M

Ant. recog.

54

Complement component C4

NP_001159957

C/M

Mod. Infl. response

55

Complement component C5

NP_001160088

C

Antimicrobial.

56†

Complement component C7

DAA17890

C

Antimicrobial.

57

Complement factor B

NP_001035616

M

Mod. Infl. response

58†

Complement factor D

Q3T0A3

C/M

Mod. Infl. response

59

Complement factor H

Q28085

C

Mod. Infl. response

60†

Complement factor I

NP_001033185

C/M

Mod. Infl. response

83†

Follistatin

AAA30522

C

Mod. Infl. response

84†

Gamma glutamyl transferase 1

DAA20447

C/M

Mod. Infl. response

85

Gelsolin

NP_001029799

C/M

Mod. Infl. response

87

GlyCAM-1

NP_777253

C/M

Ant. recog.

100

IgA heavy chain constant region

AAC98391

C/M

Ant. recog.

101

IgG1 heavy chain constant region

ABE68619

C/M

Ant. recog.

102

IgM heavy chain constant region

AAB62251

C/M

Ant. recog.

103

Immunoglobulin J chain

AAI03427

C/M

Ant. recog.

104

Ig kappa chain variable region

XP_002691399

C/M

Ant. recog.

105

Ig kappa light chain variable region

DAA24659

C/M

Ant. recog.

106

Ig lambda chain variable region

AAI51501

C

Ant. recog.

107

Ig lambda light chain constant region

AAI42356

M

Ant. recog.

108

Iglambda light chain variable region

AAI02190

C/M

Ant. recog.

109

Ig lambda-like polypeptide-1

NP_001077269

C/M

Ant. recog.

110

Inter-alpha (globulin) inhibitor H4

Q3T052

M

Mod. Infl. response

125

Lactoferrin

AAA30610

C/M

Antimicrobial.

126

Lactoperoxidase

NP_776358

C/M

Antimicrobial.

129

Lipocalin 2

XP_605012

C/M

Antimicrobial.

130

Lipopolysaccharide-binding protein

Q2TBI0

C/M

Ant. recog.

133†

Mannose-binding protein C

O02659

C

Ant. recog.

134

Mucin-1

Q8WML4

C/M

Antimicrobial.

136

Myeloperoxidase

NP_001106769

M

Antimicrobial.

139

Osteopontin

P31096

C/M

Mod. Infl. response

140 †

PAUF

XP_002697974

C?M

Mod. Infl. response

141

Peptidoglycan recognition protein-1

NP_776998

C/M

Ant. recog.

142

Peptidyl-prolyl cis-trans isomerase A

P62935

C/M

Mod. Infl. response

143†

Peptidyl prolyl cis-trans isomerase B

P80311

C/M

Mod. Infl. response

147

Platelet glycoprotein-4 (PAS IV/CD36)

P26201

C/M

Ant. recog.

148

Polymeric immunoglobulin receptor

NP_776568

C/M

Ant. recog.

150

Prostaglandin D2 synthase 21 kDa

O02853

C/M

Mod. Infl. response

164

S100 calcium-binding protein A12

P79105

C/M

Mod. Infl. response

165

S100 calcium-binding protein A8

NP_001107197

M

Mod. Infl. response

166

S100 calcium-binding protein A9

NP_001039793

C/M

Mod. Infl. response

173

Serum amyloid A3

ACL13307

M

AP response/Ant. recog.

174†

Serum amyloid A3.2

XP_875660

C/M

AP response/Ant. recog.

175 †

Serum amyloid P-component

Q3T004

C

AP response/Ant. recog.

185†

Thrombospondin-1

Q28178

C/M

Mod. Infl. response

187†

Transforming growth factor beta-2

P21214

C/M

Mod. Infl. response

192

Vitamin D-binding protein

Q3MHN5

C/M

Mod. Infl. response

193

Xanthine dehydrogenase/oxidase

NP_776397

C/M

Antimicrobial.

194

Zinc-alpha-2-glycoprotein

Q3ZCH5

C/M

Ant. recog.

195

Zymogen granule membrane GP-2

NP_001069418

C/M

Ant. recog.

  1. *denotes a peptide that maps to multiple members of the protein family, as listed in parentheses.
  2. aSpot numbers match those from Additional file 2.
  3. bC = control; M = mastitic.
  4. cAnt. Recog. = antigen recognition; AP response = acute phase response; Mod. Infl. response = modulates inflammatory response.
  5. Entries in bold text denote proteins not previously reported as present in milk.
  6. †denotes not previously reported as changed in abundance in response to infection.
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Proteome Science

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