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Figure 1 | Proteome Science

Figure 1

From: The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry

Figure 1

A schematic diagram illustrating medial forebrain bundle lesioning used to detach the striatum from dopaminergic innervation. A sagittal section from a non-lesioned rat brain, stained with an antibody to tyrosine hydroxylase (TH), highlights how dopaminergic cells residing in the substantia nigra pars compacta (SNc) extend long axonal fibers through the medial forebrain bundle on their way to innervating the striatum (Str). For lesioning, a small glass capillary (vertical arrow) was filled with 6-OHDA and lowered to a point between the SNc and Str (i.e., along the medial forebrain bundle). The 6-OHDA was slowly injected (black dot with halo surrounding) to produce a gradual degeneration of SNc dopamine neurons and their axonal innervation of the striatum. Rostral is left, dorsal is up. Scale bar = 2 mm.

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ISSN: 1477-5956