Figure 4

Glial fibrillary acidic protein (GFAP) immunoreactivity is increased at 3, 7 and 14 days post-lesioning. Glial fibrillary acidic protein (GFAP) immunoreactivity in coronal sections through the unlesioned and lesioned side of striatum from control (unlesioned), 3 days-, 7 days-, and 14 days-post-lesioned animals. At 3 days following 6-OHDA injection along the medial forebrain bundle, widespread and intense GFAP immunoreactivity can be seen in astrocytes throughout the entire striatal complex. Though this level of astrocyte reactivity had subsided somewhat by 7 days post lesioning, the level of GFAP expression in the striatum did not return to the levels seen in the unlesioned brain even after 14 days post lesioning. Scale bar for figures = 10 μm.