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Table 2 Differentially expressed proteins at 7 days post-lesioning

From: The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry

Protein name

Average iTRAQ ratio

(7 days post-lesion/unlesioned)

p value

Down-regulated

Protein phosphatase 1 regulatory subunit 1B (DARPP32) [61889054]

0.60 +/− 0.37 [6]

0.0321

Complexin-2 [5729783]

0.62 +/− 0.13 [4]

0.0057

Adh5 protein [54035294]

0.64 +/− 0.14 [3]

0.0335

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [13489075]

0.71 +/− 0.30 [9]

0.0018

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4 [68341995]

0.73 +/− 0.14 [3]

0.0507

Microsomal Cytochrome B5 [6980893]

0.74 +/− 0.06 [3]

0.0115

Neuron-specific calcium-binding protein hippocalcin [6754240]

0.74 +/− 0.18 [8]

0.0042

Up-regulated

Macrophage migration inhibitory factor [694108]

1.25 +/− 0.14 [3]

0.0537

Guanine nucleotide-binding protein G(z) subunit alpha [6980966]

1.27 +/− 0.10 [3]

0.0304

Clathrin-associated protein 17 [1809320]

1.30 +/− 0.14 [3]

0.0399

ApoE [202959]

1.32 +/− 0.20 [4]

0.0278

Brain acid soluble protein 1 [11560135]

1.33 +/− 0.71 [10]

0.0292

Gamma-enolase [26023949]

1.33 +/− 0.75 [16]

0.0165

Astrocytic phosphoprotein PEA-15 [4505705]

1.34 +/− 0.28 [4]

0.0481

Microtubule-associated protein RP/EB family member 3 [39930509]

1.39 +/− 0.65 [6]

0.0479

Platelet-activating factor acetylhydrolase IB subunit alpha [7305363]

1.39 +/− 0.09 [3]

0.0130

Beta-enolase [126723393]

1.40 +/− 0.96 [10]

0.0400

Synaptic vesicle glycoprotein 2B [17105360]

1.44 +/− 0.26 [6]

0.0042

Thiomorpholine-carboxylate dehydrogenase [16758840]

1.46 +/− 0.33 [4]

0.0312

Protein IMPACT [58866042]

1.49 +/− 0.12 [3]

0.0126

Sorting and assembly machinery component 50 homolog [51948454]

1.59 +/− 0.21 [3]

0.0233

Guanine deaminase [148747414]

1.59 +/− 1.04 [14]

0.0097

LanC-like protein 2 [62079109]

1.73 +/− 0.30 [4]

0.0094

Glial fibrillary acidic protein [158186732]

1.94 +/− 0.87 [8]

0.0047

  1. Proteins altered at 7 days post-lesion after strict filtering of the raw data. The significance of the difference between the average iTRAQ ratios for each protein at 7 days post-lesion, compared to the unlesioned control was calculated by analysing peptide ratios (see Additional file 2: Table S2) using a one-tailed, Student’s pairwise t-test. Only significant changes (i.e. those with p values of <0.05) are shown. Column headings refer to the following: protein name = given name in NCBInr database, [NCBI accession number]; Average iTRAQ ratio (7 days post-lesion/unlesioned) = average iTRAQ after data normalisation, +/− standard deviation from mean, [n] = number of peptides used for quantification.
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Proteome Science

ISSN: 1477-5956