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Table 3 Differentially expressed proteins at 14 days post-lesioning

From: The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry

Protein name

Average iTRAQ ratio (14 days post-lesion/unlesioned)

p value

Down-regulated

Importin subunit beta-1 [8393610]

0.59 +/− 0.37 [5]

0.0407

Complexin-2 [5729783]

0.59 +/− 0.16 [4]

0.0068

Annexin A6 [130502086]

0.61 +/− 0.37 [7]

0.0263

Myelin basic protein isoform 4 [70166270]

0.67 +/− 0.21 [15]

3.27E-06

Protein phosphatase 1 regulatory subunit 1B (DARPP32) [61889054]

0.67 +/− 0.15 [6]

0.0019

Myelin basic protein [4454317]

0.68 +/− 0.24 [14]

2.76E-05

Plasma membrane calcium-transporting ATPase 3 [158138481]

0.69 +/− 0.14 [6]

0.0018

Cystatin C [227013]

0.71 +/− 0.14 [3]

0.0522

High molecular-weight neurofilament [2642598]

0.73 +/− 0.27 [8]

0.0074

Myelin-oligodendrocyte glycoprotein precursor [158262022]

0.73 +/− 0.08 [5]

0.0011

Myelin proteolipid protein [13591880]

0.74 +/− 0.24 [17]

0.0001

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [13489075]

0.74 +/− 0.24 [9]

0.0039

3',5'-cyclic nucleotide phosphodiesterase 1B [12083681]

0.75 +/− 0.26 [9]

0.0091

Up-regulated

Mu Class Glutathione S-Transferase [442967]

1.25 +/− 0.22 [9]

0.0050

Chain A, Tetra-(5-Fluorotryptophanyl)-Glutathione Transferase [4388948]

1.25 +/− 0.22 [9]

0.0051

Chain A, Tetradeca-(3-Fluorotyrosyl)- Glutathione S-Transferase [5107744]

1.26 +/− 0.25 [7]

0.0182

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like [32996721]

1.27 +/− 0.16 [4]

0.0244

V-type proton ATPase subunit B, brain isoform [17105370]

1.27 +/− 0.39 [9]

0.0250

Voltage dependent anion channel [4105605]

1.27 +/− 0.42 [10]

0.0248

Hyaluronan and proteoglycan link protein 1 [1346731]

1.27 +/− 0.32 [6]

0.0402

RNA binding protein p37 AUF1 [9588102]

1.29 +/− 0.48 [6]

0.0565

Clathryn light chain (LCA2) [203276]

1.29 +/− 0.20 [4]

0.0336

Synapsin-1 isoform b [160707907]

1.29 +/− 0.43 [18]

0.0020

Neural cell adhesion molecule long domain form [281037]

1.31 +/− 0.48 [6]

0.0516

Glutathione S-transferase Yb-3 [13592152]

1.31 +/− 0.28 [7]

0.0116

Synapsin-2 isoform 1 [77404242]

1.33 +/− 0.30 [12]

0.0007

ADP-ribosylation factor 5 [4502209]

1.36 +/− 0.16 [3]

0.0359

Guanine deaminase [148747414]

1.40 +/− 0.83 [14]

0.0126

Glial fibrillary acidic protein [158186732]

1.53 +/− 1.00 [8]

0.0321

Thiomorpholine-carboxylate dehydrogenase [16758840]

1.53 +/− 0.49 [4]

0.0592

LanC-like protein 2 [62079109]

1.54 +/− 0.43 [4]

0.0406

Synaptic vesicle glycoprotein 2B [17105360]

1.56 +/− 0.44 [6]

0.0088

Sorting and assembly machinery component 50 homolog [51948454]

1.94 +/− 0.58 [3]

0.0524

  1. Proteins altered at 14 days post-lesion after strict filtering of the raw data. The significance of the difference between the average iTRAQ ratios for each protein at 14 days post-lesion, compared to the unlesioned control was calculated by analysing peptide ratios (see Additional file 2: Table S2) using a one-tailed, Student’s pairwise t-test. Only significant changes (i.e. those with p values of <0.05) are shown. Column headings refer to the following: protein name = given name in NCBInr database, [NCBI accession number]; Average iTRAQ ratio (14 days post-lesion/unlesioned) = average iTRAQ after data normalisation, +/− standard deviation from mean, [n] = number of peptides used for quantification.
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