Figure 4

Changes in subcellular localization patterns from the myofibre to the MTJ region illustrated for selected proteins. Note that desmin, αB crystallin and anexin I appear to fill the NMJ region on the muscle side beyond their z-disc localization. Telethonin (z-disc) and myomesin (M line) appear to increase their concentration at the most terminal sarcomeres without changing their characteristic banding patterns. For comparison, the MTJ pattern of α-syntrophin is also shown. All pictures taken with a 63x oil lense with variables zoom factors applied. All scale bars indicate 10 microns.