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Table 2 Results of VEGF expression by immunohistochemical staining and well-based Reverse Phase Protein Array (RPPA)

From: Assessment of vascular endothelial growth factor in formalin fixed, paraffin embedded colon cancer specimens by means of a well-based reverse phase protein array

Factor

Characteristics

Quantitation method

  

IHC

Well-based RPPA

  

VEGFa

P-value

VEGFb

P-value

Gender

Male

8.7

0.07

2.4

0.03*

Female

12.5

 

3.1

 

Differentiation

Well

20.0

0.04*

4.2

0.04*

Moderately

10.9

 

2.9

 

Poorly

9.1

 

2.5

 

Histologic type

Adenocarcinoma

9.6

0.27

2.8

0.29

Mucinous carcinoma

11.9

 

2.5

 

T classification

T1

8.0

0.24

2.1

0.10

T2

6.1

 

2.9

 

T3

11.9

 

3.0

 

T4

9.1

 

2.3

 

N classification

N0

12.4

0.16

3.1

0.05

N1

8.3

 

2.5

 

N2

8.3

 

2.3

 

Vascular invasion

Absent

10.3

0.93

2.8

0.60

Present

10.0

 

2.6

 
  1. aHisto-score was generated as the product of intensity times area.
  2. bAfter normalization with GAPDH level, relative expressional signals were represented as a ratio.
  3. *Significant at the level of P < 0.05.
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Proteome Science

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