The use of proteomics in identifying differentially expressed serum proteins in humans with type 2 diabetes

Table 2 Differentially expressed proteins in serum from normal glucose tolerant and type 2 diabetes mellitus individuals

Amounts of serum proteins were determined by calculating heights of peaks found in SELDI-TOF mass spectra using the immobilized metal affinity capture (IMAC30) and cationic exchanger (CM10) arrays. Serum samples were obtained from three normal glucose tolerant (NGT) and three type 2 diabetes mellitus (T2DM) subjects. Protein masses, after applying inclusion criteria (signal to noise ratio > 10, percentage of peaks > 20%) on the spectra, are indicated. Significant (p < 0.05, Mann-Whitney U-test) up- (↑) and down (↓) regulations are noted.

ISSN: 1477-5956