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Table 2 Anti-PY binding proteins – 60 min reperfusion

From: Proteomic analysis of tyrosine phosphorylation during human liver transplantation

Protein name Accession number Mascot score Sequence Coverage Peptide number Subellular Localization Biological Function Reported PY sites* Predicted PY sites+
Actin, cytoplasmic 2 P63261 664 42% 19 cytosol cytoskeleton none 108,164,365,476,521
Carbamoyl-phosphate synthetase 1 Q5R206 538 9% 11 mitochondrion detoxification none 443,634,768,852,872,957, 959,1032,1305,1450
60S ribosomal protein L7 P18124 495 45% 10 cytosol-nucleus protein metabolism none 51,155,159,182
Serum albumin precursor P02768 393 17% 8 secreted transport none 108,164,365,476,521
Alcohol dehydrogenase [NADP+] P14550 387 21% 8 cytosol detoxification none 49,139,240,324
Unknown (protein for MGC:22633) BC022319 1 375 21% 8 unknown unknown none 14,341
Dihydrolipoamide branched chain transacylase P11182 349 17% 8 mitochondrion energy metabolism none 36,85,130
Myosin heavy chain P13533 316 6% 7 cytosol cytoskeleton none 162,284,311,387,411,502, 1377,1462,1490,1854
Protein disulfide isomerase-related protein Q14554 218 10% 3 ER protein metabolism none 113,222,242,245,357,364, 488
60S ribosomal protein L6 Q02878 217 16% 4 cytosol-nucleus protein metabolism none 68,72,239
60S ribosomal protein L13a P40429 210 27% 6 cytosol-nucleus protein metabolism none 53,191
60S ribosomal protein L18 Q07020 175 24% 4 cytosol-nucleus protein metabolism none 23,165
60S ribosomal protein L5 P46777 143 12% 3 cytosol-nucleus protein metabolism none 29,30,43,48,144,182,218, 239, 252
Enoyl-CoA hydratase P30084 107 3% 2 mitochondrion energy metabolism none 35
Very-long-chain acyl-CoA synthetase O14975 102 4% 2 ER detoxification none 81, 117, 261, 413, 460, 553, 610
Ku antigen, 70 kD NP001460 2 102 4% 2 nucleus nucleobase metabolism none 8, 30, 103, 361, 534, 559
Alpha-s1-casein P47710 102 10% 2 secreted transport none none
60S ribosomal protein L8 P62917 99 9% 3 cytosol-nucleus protein metabolism 132 none
40S ribosomal protein S4 P62701 94 4% 1 cytosol-nucleus protein metabolism none 53, 120
Tubulin beta-1 chain Q9H4B7 92 8% 5 cytosol cytoskeleton none 55, 106, 222, 310
Complement C1q subcomponent subunit A P02745 86 6% 2 secreted blood coagulation none 144
ATP-dependent RNA helicase A Q08211 83 3% 2 cytosol nucleobase metabolism none 9,21,43,45,149,200,218,616,727748,1155,1167,1189,1194, 1234
Galactokinase P51570 69 4% 1 cytosol energy metabolism none 47,318
40S ribosomal protein S2 P60866 69 5% 2 cytosol-nucleus protein metabolism none none
Beta-casein P05814 65 8% 2 secreted transport none 32,109
Phosphoenolpyruvate carboxykinase P35558 64 2% 1 mitochondrion energy metabolism none 165,279,595
40S ribosomal protein S3 P23396 64 3% 1 cytosol-nucleus protein metabolism none 36,87,107, 67
Alpha-fetoprotein P02771 62 3% 1 secreted transport none 60, 151, 164, 426, 505, 521
ATP synthase beta chain P06576 50 3% 1 mitochondrion energy metabolism none 247, 418
Tubulin alpha-ubiquitous chain P68363 48 2% 1 cytosol cytoskeleton 272 210,224,399,432,451
Heterogeneous nuclear ribonucleoprotein AB Q53F64 48 4% 1 cytosol-nucleus protein metabolism none 235,272,307
Vimentin P08670 44 4% 2 cytosol cytoskeleton 116 10,29,52,275,290
Histone H1.3 P16402 44 11% 1 nucleus nucleobase metabolism none none
Fibrinogen gamma chain P02679 42 3% 1 secreted blood coagulation none 27,140,288,300,444,448
Alpha-tropomyosin P09493 39 1% 1 cytosol cytoskeleton none 60,162,214,221,261,267
ATP synthase alpha chain P25705 39 2% 1 mitochondrion energy metabolism none 299,476
60S ribosomal protein L4 P36578 37 3% 1 cytosol-nucleus protein metabolism none 160
  1. Proteins identified in the 60 min ischemia and the 60 min reperfusion fractions are represented in italic.
  2. Database: SwissProt except 1EMBL and 2GenBank
  3. *source: SwissProt and Human Protein Reference Database
  4. + source: NetPhos 2.0