Table 3 Predicted transcription factors from the genes of the most relevant age-related proteins in this study.

TF vs PROT

CAT

ACOX1

ACCA1A

EHHADH

PHYH

HMGCS2

HMGCL

AGXT

DAO1

MRGPRF

Conserved

Model

RXR-ALPHA

1

1

1

1

1

1

1

no

T01331

SPZ1

1

1

1

1

1

1

1

1

1

yes

MA0111

NF-Y

1

1

1

1

1

yes

M00775

SP-1

1

1

1

1

1

1

1

no

M00931

PAX

1

1

1

1

1

1

1

1

no

M00979

PPARG

1

1

1

1

no

M00512

ZIC

1

1

1

no

M00448

BSAP

1

1

1

no

MA0014

COEI

1

1

no

T01112

CAC-BINDING PROTEIN

1

1

no

M00720

HOX-1.3

1

1

1

yes

M00023

KROX

1

1

1

no

M00982

SOX

1

1

1

1

1

1

no

MA0078

MEF-1,2

1

1

1

1

no

T00505

BRACHYURY

1

1

1

no

MA0009

MTF-1

1

1

1

no

T00515

ZF5

1

1

no

M00333

ARNT

1

1

1

1

1

no

MA0004

IRF-1

1

1

1

1

no

M00062

EGR

1

1

1

1

no

M00807

PPAR DIRECT REPEAT 1

1

1

no

M00763

PPAR , HNF-4, COUP, RAR

1

1

no

M00762

N-MYC

1

1

no

MA0104

ELF1

1

1

no

M00746

PPARALPHA:RXR-ALPHA

1

1

1

1

no

M00518

C_EBP

1

1

1

no

M00912

NF-KAPPAB

1

1

no

M00774

CRX

1

1

1

1

no

M00623

C/EBPBETA

1

1

1

no

M00109

LYF-1

1

1

1

1

no

T00479

FOX

1

1

1

1

no

T04203

HSF

1

1

1

1

1

no

T00384

CP2

1

1

yes

M00072

SF-1

1

1

no

T01147

EVI-1

1

1

1

no

M00081

AHR-ARNT

1

1

1

no

MA0006

CART-1

1

1

yes

T03999

ALX-4

1

1

yes

T02967

CREB

1

1

no

M00114

SRF

1

1

1

1

no

M00922

MYOD

1

1

1

1

no

M00929

MYOGENIN

1

1

1

1

no

M00712

NKX2-2

1

1

no

T02384

E2A

1

1

1

no

M00804

USF

1

1

no

M00796

MAF

1

1

no

M00983

PU.1

1

1

no

T00702

LMO2 COMPLEX

1

1

no

M00277

P53 DECAMER

1

1

no

M00761

TCF-1(P)

1

1

no

M00670