Proteomic profile determination of autosomal aneuploidies by mass spectrometry on amniotic fluids

Table 2 Diagnostic performance of classifiers

				Tested population		General population
Model	Accuracy	Sensitivity	Specificity	PPV	NPV	PPV	NPV
SVM multiprotein index
Learning population	92.86	93.33	92.31	93.33	92.31	1.50	99.99
Testing population	87.50	83.33	83.33	83.33	83.33	0.62	99.97
Logistic regression multiprotein index
Learning population	96.43	93.33	100.00	100.00	92.86	100.00	99.99
Testing population	91.67	83.33	100.00	100.00	87.71	100.00	99.98

Positive Predictive Value (PPV) and Negative Predictive Value (NPV) were estimated for the tested population and for the general population (with a prevalence of 1/800).

ISSN: 1477-5956