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Table 1 Differentially regulated proteins commonly found in two different tumours, SM5 and SM7

From: Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53

Protein

Identification

Peptide sequence

Charge

Mascot Score

Mr (Da)

pI

SM5 versus Wta

SM7 versus Wtb

1236

Rho GDP-dissociation inhibitor 2/Ly-GDI GDIS_MOUSE

LNYKPPPQK (20–28)

2

116

21,754

6.81

Up

Up

  

TLLGDVPVVADPTVPNVTVTR (49–69)

2

     
  

YVQHTYR (123–129)

2

     

1062

Proteasome subunit α type 3 PSA3_MOUSE

SSIGTGYDLSASTFSPDGR (1–19) (Acetyl N-term)

2

112

27,861

5.37

Up

Up

  

AVENSSTAIGIR (29–40)

2

     

131

Transforming acidic coiled-coil containing protein 3/ARNT-interacting protein TACC3_MOUSE

GLLPAEPIVDVLK (416–428)

2

31*

88,566

4.04

Up

Up

  

AQAEVLALQASLR (582–594)

2

     

653

Ornithine aminotransferase, mitochondrial OAT_MOUSE

TEQGPPSSEYIFER (33–46)

2

147

43,842

6.56

Up

Up

  

LFNYNK (130–135)

2

     
  

LPSDVVTSVR (363–372)

2

     
  

ESVEIINK (427–434)

2

     

1468

Fatty acid binding protein, epidermal FABPE_MOUSE

FDETTADGR (72–80)

2

66

14,264

6.62

Up

Up

622

Adenylosuccinate synthetase PURA2_MOUSE

VVDLLAQDADIVCR (46–59)

2

140

45,185

6.95

Up

Up

  

ELPVNAQNYVR (420–430)

2

     
  

FIEDELQIPVK (431–441)

2

     

830/845

Tubulin β-3 chain TBBX_MOUSEc

AILVDLEPGTMDSVR (63–77)

2

36

36,980/36,445

6.26/6.25

Up

Up

1123

Actin (C-terminal) ACTX_MOUSEd

DLTDYLMK (184–191)

2

43

25,609

5.70

Down

Down

  

EITALAPSTMK (316–326)

2

     

1284

Proteasome subunit β type 9/LMP-2d PSB9_MOUSE

VSAGTAVVNR (40–49)

2

129

19,837

4.42

Down

Down

  

FTTDAITLAMNR (174–185)

2

     
  

VILGDELPK (207–215)

2

     

1357

Cofilin-1 COF1_MOUSE

YALYDATYETK (81–91)

2

65/65

17,159

7.16

Down

Down

1363/1367

Cofilin-1 COF1_MOUSE

YALYDATYETK (81–91)

2

20**

17,199

6.38

Down

Down

1382

Glia maturation factor γ GMFG_MOUSE

FVVYSYK (68–74)

2

117/75

16,626

5.56

Down

Down

  

LVQTAELTK (111–119)

2

     
  

TTDDLTETWLK (125–135)

2

     
  1. The significance level for the peptides given were p < 0.05 when searching in the total database except the protein indicated with (*) that was significant when searching in the mouse part of the database and the peptide given with (**) that was not significant. The non-significant peptide (1363/1367) was included because of the similarity to the significant peptide 1357.
  2. a Up, protein that is up-regulated in SM5 cells versus wt. Down, protein that is down-regulated in SM5 cells versus wt.
  3. b Up, protein that is up-regulated in SM7 cells versus wt. Down, protein that is down-regulated in SM7 cells versus wt.
  4. c X is 2A, 2B, 3 or 5
  5. d X is A, B, C, G, H or S