Table 4 Functional annotation clustering of proteins involved in the transformation of tumour cell line SM5

Purine nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.

PURA2

0.0039

NKDB

ATPA

Cellular process

Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

H4

0.047

PSB9

TBB3

VINC

IF34

PURA2

ENOA

IF2A

ATPA

P4HA1

FABPE

COF1

TPIS

TACC3

PSA3

NDKB

ACTB

PCBP1

OAT

Glucose metabolic process

The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.

TPIS

0.006

ENOA

FABPE

Translation factor activity, nucleic acid binding

Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome.

IF34

0.011

IF2A

PCBP1

Actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

COF1

0.022

VINC

ACTB

ATP binding

Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

NDKB

0.48

ATPA

ACTB

Regulation of cellular process

Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

COF1

0.76

VINC

TACC3

IF2A