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Table 1 Defense and immunity proteins

From: The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome

  

Normalized Volumes Mean (SD)

WTFA vs WTO3

p ≤ 0.05

Normalized Volumes Mean (SD)

KOFA vs KOO3

p ≤ 0.05

WTFA vs KOFA

p ≤ 0.05

WTO3 vs KOO3

p ≤ 0.05

  

WTFA

WTO3

 

KOFA

KOO3

   

Adipsin (complement factor D)

↑

2.05

(0.337)

2.43

(0.610)

 

2.13

(0.742)

2.34

(0.655)

   

Alpha-1-antitrypsin 1-1

↓

1.18

(0.191)

1.04

(0.102)

 

1.35

(0.369)

0.94

(0.210)

   

Alpha 1-antitrypsin 1-6

↑

2.15

(.230)

2.94

(0.353)

*

2.85

(0.484)

3.47

(0.712)

 

*

 

Annexin A1

↓

3.05

(0.168)

2.57

(0.381)

.058

2.73

(0.409)

2.38

(0.517)

   

Annexin A5

↑

1.10

(0.155)

1.30

(0.251)

 

0.58

(0.078)

1.04

(0.171)

*

*

 

Antithrombin-III

↑

3.08

(0.589)

4.54

(0.659)

*

3.53

(0.342)

4.78

(0.454)

*

  

Apolipoprotein A-I

↑

1.59

(0.300)

2.18

(0.350)

*

2.24

(0.668)

4.41

(1.038)

*

 

*

Chain A, Mammalian

Lectin Ym1

↓

3.78

(1.000)

2.76

(0.290)

 

3.03

(0.053)

1.97

(0.903)

.058

  

Chia protein

↓

1.20

(0.244)

0.88

(0.172)

.075

1.49

(0.367)

0.82

(0.354)

*

  

Chitinase-3-like protein 1 precursor (GP-39)

↓

11.19

(1.860)

7.35

(1.959)

*

9.26

(2.089)

4.46

(1.843)

*

  

Complement

component C3

↑

0.65

(0.142)

1.04

(0.212)

*

0.74

(0.248)

1.24

(0.261)

*

  

Complement

component C5

↓

7.26

(0.617)

6.88

(0.999)

 

7.32

(0.692)

6.08

(0.766)

.053

  

Esterase 1

↑

2.73

(0.187)

3.85

(0.960)

*

3.31

(0.220)

4.44

(0.687)

*

*

 

Ferritin (light chain)

↓

1.43

(0.325)

1.21

(0.180)

 

1.34

(0.382)

1.13

(0.380)

   

Gluthathione S-transferase A4 (GST A4-4)

↓

1.41

(0.153)

0.80

(0.445)

*

1.32

(0.148)

0.65

(0.146)

*

  

Glutathione S-transferase omega 1

↓

3.52

(0.140)

2.78

(0.416)

*

2.94

(0.422)

2.77

(0.986)

 

*

*

Haptoglobin

↓

12.71

(2.040)

11.21

(0.835)

 

11.47

(0.326)

7.61

(0.764)

*

  

Heat shock protein 1, alpha

↑

0.75

(0.092)

0.95

(0.114)

*

0.70

(0.164)

0.95

(0.076)

*

  

Heat shock protein 70

↑

3.93

(0.807)

5.82

(1.173)

*

4.64

(0.556)

7.79

(1.026)

*

  

Kininogen 1

↑

5.36

(1.723)

6.99

(0.703)

 

5.89

(0.514)

7.65

(0.456)

*

  

Lactate dehydrogenase 2, B chain

↓

1.26

(0.417)

1.03

(0.520)

 

1.05

(0.179)

0.84

(0.062)

.072

  

Murinoglobulin-1 precursor (MuG1)

↑

0.77

(0.166)

1.07

(0.136)

*

0.88

(0.073)

1.26

(0.131)

*

  

Peroxiredoxin 6 (Antioxidant protein 2)

↓

5.60

(0.884)

3.35

(1.694)

.057

5.39

(0.486)

3.11

(0.667)

*

  

Plasminogen

↓

8.39

(1.194)

7.35

(0.653)

 

8.82

(0.775)

7.70

(2.054)

   

Pregnancy zone protein

↑

0.76

(0.166)

0.83

(0.059)

 

0.94

(0.343)

1.05

(0.080)

   

Prothrombin precursor

(EC 3.4.21.5)

↑

1.42

(0.171)

2.01

(0.423)

*

1.56

(0.167)

2.15

(0.301)

*

  

Pulmonary surfactant-assoc. protein A (SP-A)

↓

36.21

(7.512)

29.07

(6.055)

 

-

'-

 

*

 

Selenium binding protein 1

↓

1.42

(0.177)

0.83

(0.402)

*

1.39

(0.212)

0.68

(0.105)

*

  

Selenium binding protein 2

↓

5.61

(0.794)

3.53

(1.407)

*

5.33

(0.742)

3.00

(0.472)

*

  

Similar to Glutathione S-transferase Ya chain

↓

1.53

(0.166)

0.94

(0.443)

*

1.43

(0.174)

0.83

(0.216)

*

  
  1. The proteins assigned to the defense and immunity category (DEF) are listed (n = 30). An arrow indicates whether levels of expression are increased (↑) or decreased (↓) in response to ozone. The mean values for the normalized volumes and standard deviations for each named protein are given for WTFA, WTO3, KOFA, and KOO3. The asterisk indicates whether the p-value for the comparisons of WTFA vs. WTO3; KOFA vs. KOO3; WTFA vs. KOFA; and WTO3 vs. KOO3 was ≤ 0.05. Values that were slightly above 0.05 are also given.
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Proteome Science

ISSN: 1477-5956