Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion

Table 3 Glucose and palmitate-regulated INS-1E proteins

Gene name	Primary accession no.	Ncbi accession no.	No. peptides matched	Seq cov (%)	Mowse score
Calm1, Calm3	P62161	NP_114175.1 NP_036650.1	4	42	90
G6pdx, G6pd	P05370	NP_058702	29	40	176
Ganab		NP_001099804	19	25	191
Gars	Q5I0G4	AAH88347	19	40	155
Hnrnpa3, Hnrpa3	Q6URK4	NP_444493		23	105
Lonp1, Lon, Prss15	Q924S5	NP_596895	15	18	143
Ndufv1	Q5XIH3	NP_001006973	17	37	194
Pgk1, Pgk-1	P16617	NP_445743	15	52	131
Psmc5	O35050	BAA22935	17	41	190
Rab2	P05712	EDM11646	9	55	108
RGD1561681_predict.		XP_001054125	27	58	257
Tcp1, Cct1, Ccta	P28480	NP_036802	18	34	146

INS-1E cells were cultured at 5.5 or 20 mM glucose in the absence or presence of palmitate for 48 hours. After culture, cells were lysed and protein profiled. Differentially expressed proteins by glucose or palmitate were identified by peptide mass fingerprinting.

ISSN: 1477-5956