Figure 1

Histological examination of regenerating mouse livers following 50% PH. Fig.1(A) Liver histology slide of sham-operation group (HE staining 400×) showing clear hepatic lobule, radial liver cell cord, and clear hepatic sinusoid; Fig.1(B) Liver histology slide of 50% PH group 1 day after operation (HE staining 400×) showing cloudy swelling of some hepatocytes with focal piecemeal necrosis, and hepatocytes with multiple and enlarged nuclei started to appear. Fig.1(C) Liver histology slide of 50% PH group 3 days after operation (HE staining 400×) showing the majority of hepatocytes with double, multiple nuclei or single enlarged nuclei, prominent nucleoli, and cytoplasmic acidophilic bodies; Fig.1(D) Liver histology slide of 50% PH group 13 days after operation (HE staining 400×) showing double or enlarged nuclei but less prominent acidophilic bodies in most hepatocytes; Fig.1(E) Liver histology slide of 50% PH group 25 days after operation (HE staining 400×) showing double or enlarged nuclei still present in many hepatocytes which contain much reduced acidophilic bodies.