Figure 4
From: Proteomic analysis of regenerating mouse liver following 50% partial hepatectomy
Pathway analysis result showing 18 differentially expressed proteins following 50% PH can be sorted into the c-myc pathway. There are 18 root nodes in the sub-network shown, of which ACAA2, ALDH2, ACOX1, GSTP1, ACADM, ASS1(ASSY) are up-regulated and VDAC1, MGST, RPL11, ALDX, RPS5 are "newly-induced" in response to 50% PH; ACTG1(Actin cytoplasmic 2), HSPA8(HSC70), CAT(catalase) are down-regulated and FAH(FAAA), NDUFS3, RPS10, eEF1A2 are below detection limit. These root nodes are connected to c-Myc directly or indirectly, and their expression levels or activities can be regulated by c-Myc, and some of them (such as RPL11) can regulate c-Myc activity in a feedback manner. Legend describing symbols in the network can be found in Additional file 1.