Alterations in the red blood cell membrane proteome in alzheimer's subjects reflect disease-related changes and provide insight into altered cell morphology

Table 2 Alteration in the level of RBC membrane/cytoskeletal proteins similar to those alterations in AD or its animal model

Accession No.	Fold Change (AD/Normal)	Protein Name	Citations showing Similar fold changes
IPI00008274	8.13	Adenylyl cyclase-associated protein	[27]
IPI00010314	1.78	Aminolevulinate, delta-, dehydratase	[30]
IPI00024689	2.61	Aquaporin-CHIP (Aquaporin-1, AQP-1, AQP1)	[36]
IPI00027462	3.38	Calgranulin B (S100A9)	[37]
IPI00233820	2.61	Catalase*	[54, 55]
IPI00027438	1.89	Flotillin-1	[38]
IPI00328602	123.42	heat shock 90 kDa protein 1, alpha	[33, 56]
IPI00217966	634.23	L-lactate dehydrogenase A*	[39]
IPI00298860	2.88	Lactotransferrin precursor (Lactoferrin) [Contains: Lactoferroxin A	[40]
IPI00218342	31.93	Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1)	[41]
IPI00022434	2.08	Serum albumin precursor	[43]
IPI00180818	0.18	Aldolase A *	[44]
IPI00026119	0.19	Ubiquitin-activating enzyme E1*	[45]

N.B. Proteins shown in bold letters have been reported by Pasini et. al. [8] to be present in RBC membrane and those with asterisks have been reported by Goodman et. al. [7] to be present in whole RBC proteome.

ISSN: 1477-5956