Figure 2

Schematic overview of the CVF proteome composition. The CVF proteome can be roughly divided into "higher" and "lower" abundant proteins. The proteins from these categories can be further subdivided based on their function and cellular localization. The term "characteristic" is used here for proteins with a function and cellular localization which is representative for the functions of CVF. "Non-characteristic" is used for proteins which presumably do not have a measurable or known significant biological function in this body fluid. For each category, a general indication of the percentage immunological and extracellular is given. Proteins from the subcategories subsequently construct the "core" and "variable" proteome.