Table 3 Comparative proteomic analysis: proteins down-regulated by Cardiogenol C in HBPCs
Proteins identified | Observed MW (kDa)/pI | Theoretical MW (kDa)/pI | Accession number | Folds decrease | Reported functions |
|---|---|---|---|---|---|
Cell division protein kinase 6 (Cdk6) | 36/6.2 | 37.0/6.2 | Q64261 | 1.7 | Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins |
Growth/differentiation factor 8 (GDF-8) | 39/6.6 | 42.9/6.6 | O08689 | 2.2 | Acts specifically as a negative regulator of skeletal muscle growth |
Kremen protein 1 precursor (Kremen1) | 63/6.5 | 51.7/6.7 | Q99N43 | 3.7 | Receptor for Dickkopf protein. Cooperation with Dickkopf to block Wnt/beta-catenin signaling |
Tight junction protein ZO-1 | 130/6.4 | 194.7/6.2 | P39447 | 1.4 | The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions |
Transcription factor ETV6 | 60/6.5 | 56.4/6.8 | P97360 | 3.6 | Transcription repressor; binds to the DNA sequence 5' CCGGAAGT-3' |
Tyrosine protein kinase Srms | 56/6.6 | 55.8/6.7 | Q62270 | 1.5 | May be involved in proliferation or differentiation of keratinocytes in the skin |