Figure 2

Comparison of cluster properties - connectedness vs. compactness. This figure shows each four selected clusters that resulted from two hierarchical cluster analyses using Single-Linkage (on the left side) and Complete-Linkage (on the right side). These results demonstrate the two opposing properties of a clustering connectedness and compactness: Single-Linkage, on the one hand, tends to group as many proteins in a cluster if there is at least a slight similarity. This often leads to one large cluster that contains most of the proteins while other clusters consist of individual outliers. Complete-Linkage, on the other hand, tries to form compact clusters that contain only those proteins that are utmost similar.