Table 2 Fold Change of Signaling Kinases Up-regulated by Constitutively Activated EGFRvIII Mutation over Time
Time | EGFR | pEGFR(Y1173) | pRaf1 | pErk | pAkt | pSrc(Y416) | pJNK | pp38 | pNF-kBp65 |
|---|---|---|---|---|---|---|---|---|---|
0 hr | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
1 hr | 2.28 | 1.14 | 0.88 | 1.36 | 1.08 | 0.99 | 1.02 | 1.01 | 1.08 |
6 hr | 7.31 | 1.75 | 0.89 | 1.89 | 1.62 | 1.51 | 1.04 | 0.91 | 1.24 |
20 hr | 23.19 | 26.19 | 1.32 | 2.76 | 1.88 | 31.35 | 2.61 | 0.93 | 0.95 |
24 hr | 22.14 | 25.11 | 1.17 | 2.77 | 1.88 | 34.39 | 2.82 | 0.88 | 0.92 |
48 hr | 26.39 | 35.62 | 1.59 | 3.79 | 2.26 | 52.79 | 4.37 | 0.99 | 1.26 |