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Table 2 Fold Change of Signaling Kinases Up-regulated by Constitutively Activated EGFRvIII Mutation over Time

From: Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions

Time EGFR pEGFR(Y1173) pRaf1 pErk pAkt pSrc(Y416) pJNK pp38 pNF-kBp65
0 hr 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
1 hr 2.28 1.14 0.88 1.36 1.08 0.99 1.02 1.01 1.08
6 hr 7.31 1.75 0.89 1.89 1.62 1.51 1.04 0.91 1.24
20 hr 23.19 26.19 1.32 2.76 1.88 31.35 2.61 0.93 0.95
24 hr 22.14 25.11 1.17 2.77 1.88 34.39 2.82 0.88 0.92
48 hr 26.39 35.62 1.59 3.79 2.26 52.79 4.37 0.99 1.26