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Figure 1 | Proteome Science

Figure 1

From: Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2

Figure 1

Morphology of sham and ACF rat hearts 150 day after ACF creation. A) Transversal section of the heart illustrates marked biventricular enlargement in the ACF animal compared to control sham-operated rats. B,C) Picrosirius Red staining in transverse sections, observed in polarized light, detected sparse mature collagen fibers (in red) well aligned with the myocyte bundles in the circular layer of the left ventricle (B). The amount of collagen was consistently higher in the right ventricle (C), but no difference between sham and ACF hearts was apparent. Green staining is due to erythrocytes, contractile proteins, or immature collagen fibrils. Very little green was observed at the edges of the collagen fibers, representing physiological protein turnover rather than tissue remodeling, with no difference between sham and ACF.

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Proteome Science

ISSN: 1477-5956